Evidence map›Paper›PMID 42075777›Full record

SynthesisPathogens (Basel, Switzerland)2026

The Role of Microbiota and Fecal Transplantation in Inflammatory Bowel Disease.

Isabel Lagos, Edith Pérez de Arce, Ilaria Faggiani, Ferdinando D'Amico, Alessandra Zilli, Federica Furfaro, Sara Massironi, Clelia Cicerone, Virginia Solitano, Tommaso Lorenzo Parigi and 3 more

Abstract readSystematic Review
In one paragraph

Synthesis in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Isabel LagosDepartment of Gastroenterology, Clinica Las Condes, Estoril 450, Santiago 8380453, Chile.ORCID 0009-0006-7556-1111
Edith Pérez de ArceDepartment of Gastroenterology, Hospital Clinico Universidad de Chile, Dr. Carlos Lorca Tobar 999, Santiago 8380456, Chile.
Ilaria FaggianiDepartment of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Via Oglettina 60, 20132 Milan, Italy.ORCID 0009-0003-4501-6700
Ferdinando D'AmicoDepartment of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Via Oglettina 60, 20132 Milan, Italy.ORCID 0000-0002-8591-6995
Alessandra ZilliDepartment of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Via Oglettina 60, 20132 Milan, Italy.
Federica FurfaroDepartment of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Via Oglettina 60, 20132 Milan, Italy.ORCID 0000-0002-4308-7295
Sara MassironiDepartment of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Via Oglettina 60, 20132 Milan, Italy.ORCID 0000-0003-3214-8192
Clelia CiceroneDepartment of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Via Oglettina 60, 20132 Milan, Italy.ORCID 0009-0003-5400-2765
Virginia SolitanoDepartment of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Via Oglettina 60, 20132 Milan, Italy.
Tommaso Lorenzo ParigiDepartment of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Via Oglettina 60, 20132 Milan, Italy.ORCID 0000-0002-3398-0231
Laurent Peyrin-BirouletDepartment of Gastroenterology, INFINY Institute, INSERM NGERE, CHRU Nancy, F-54500 Vandoeuvre-lès-Nancy, France.
Silvio DaneseDepartment of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Via Oglettina 60, 20132 Milan, Italy.
Mariangela AlloccaDepartment of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Via Oglettina 60, 20132 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn's disease (CD), are consistently associated with alterations in gut microbial communities, although the extent and characteristics of these alterations vary across studies, supporting a potential role of the microbiota in disease pathogenesis and therapeutic modulation. We conducted a systematic review to synthesize current evidence on microbiota alterations in IBD and the clinical application of fecal microbiota transplantation (FMT). A total of 118 studies were included (76 focused on microbiota profiling and 42 evaluated FMT as therapy). Across heterogeneous study designs and microbial characterization methods, reduced microbial diversity was the most consistently reported alteration, generally more pronounced in CD than in UC. Depletion of

Indexed as

Fecal Microbiota TransplantationGastrointestinal MicrobiomeInflammatory Bowel DiseasesAnimalsHumansTreatment Outcomebile acidsCrohn’s diseasefecal microbiota transplantationgastrointestinal microbiomeinflammatory bowel diseasemicrobiotaulcerative colitis

Identifiers

PMID42075777
PMCPMC13119295

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.