ReviewMedicina (Kaunas, Lithuania)2026
Adverse Childhood Experiences and Life Course Adversity Related to Geriatric Syndromes: A Narrative Review.
Review in Medicina (Kaunas, Lithuania), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesDuring the last decades, there has been a growing interest in and knowledge of the relationship between adverse childhood experiences (ACEs) or stressful life events and health issues in younger and adult populations. However, less is known in older populations. This narrative review aimed to summarize cross-syndrome studies on the relationship between life course exposure to adversity (e.g., ACEs, discrimination, famine, adult violence) and geriatric syndromes (e.g., dementia, frailty, falls, depression), with the primary intention of providing a descriptive mapping of the evidence and identifying gaps.
methodsWe searched PubMed for articles published between 2015 and 2026 using specific keywords.
resultsWe included 84 studies. There is substantial variability in the exposure measures used (e.g., for ACEs, from one question to more than 30) and in the outcomes (e.g., different diagnostic criteria for dementia or frailty).
conclusionsOur synthesis showed that ACEs, stressful events, and other adversity measures are usually associated with greater probabilities of the occurrence of geriatric syndromes such as dementia, frailty, depression, falls, low muscle strength, multimorbidity, and functional decline. There are also some reports for mediators, depression being the most common, that may partially explain those associations.
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