Evidence map›Paper›PMID 42075300›Full record

ReviewMicroorganisms2026

Managing Breakthrough Fungal Infections in Hematologic Patients: Determinants and Practical Management from a Latin American Perspective on Behalf of INFOCUS LATAM-ISHAM Working Group.

Larissa Simão Gandolpho, Daniel Aguilar-Zapata, Pablo Andrés Moncada-Vallejo, Fernando Riera, Mariana Guaraná, Giovanni Luis Breda, Ricardo Rabagliati, Marcio Nucci, Arnaldo Lopes Colombo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Larissa Simão GandolphoDivision of Infectious Diseases, Escola Paulista de Medicina da Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.ORCID 0009-0008-0959-8180
Daniel Aguilar-ZapataInfectious Diseases and Hospital Epidemiology, Mexico City 14080, Mexico.ORCID 0000-0001-7482-1301
Pablo Andrés Moncada-VallejoDepartment of Internal Medicine, Fundacion Valle del Lili, Cali 760032, Colombia.ORCID 0000-0001-9170-3016
Fernando RieraDivision of Infectious Diseases, Sanatorio Allende, Córdoba X5000, Argentina.
Mariana GuaranáHospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 20270-001, Brazil.ORCID 0000-0003-0077-4121
Giovanni Luis BredaHospital de Clínicas, Universidade Federal do Paraná, Curitiba 80060-900, Brazil.
Ricardo RabagliatiDepartment of Infectious Diseases, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.ORCID 0000-0002-0574-8312
Marcio NucciDivision of Hematology, Internal Medicine Department, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.ORCID 0000-0003-4867-0014
Arnaldo Lopes ColomboDivision of Infectious Diseases, Escola Paulista de Medicina da Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.ORCID 0000-0003-0793-8491

Funding

Fundação de Amparo a Pesquisa do Estado de São Paulo - FAPESP 2021/10599-3
6 · The paper itself

Abstract

Breakthrough invasive fungal infections (bIFIs) are a challenging serious complication in high-risk hematologic patients and allogeneic hematopoietic stem cell transplantation recipients that may negatively impact their outcome. Despite advances in antifungal prophylaxis, diagnostics, and supportive care, bIFI occurrence reflects a complex interaction between host immunosuppression, emergence of resistant pathogens and pharmacological variables, including subtherapeutic drug exposure.

Indexed as

acute myeloid leukemiaantifungal prophylaxis failureAspergillus spp.breakthrough fungal infectionsdrug resistanceFusarium spp.hematologic malignancieshematopoietic stem cell transplantationinvasive mold infectionsmucormycosisrare yeasts (SaprochaeteRhodotorula)therapeutic drug monitoringTrichosporon

Identifiers

PMID42075300
PMCPMC13118672

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.