Evidence map›Paper›PMID 42075077›Full record

ArticleNutrients2026

Lactopontin in a Simulated Infant Formula Protein Matrix Promotes Bone Development via the Gut-Bone Axis in Growing Rats.

Yipin Lyu, Jie Zhang, Chi Cheng, Xue Tang, Pantian Huang, Feitong Liu, Ruibiao Hu, Thom Huppertz, Xinyan Wang, Peng Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yipin LyuSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0001-9748-5945
Jie ZhangSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0002-2975-3917
Chi ChengSchool of Chemical Engineering and Materials, Changzhou Institute of Technology, Changzhou 213000, China.
Xue TangSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0003-3249-9953
Pantian HuangBiostime (Changsha) Nutrition Foods Limited, Changsha 410219, China.
Feitong LiuHealth and Happiness (H&H) China Limited, Guangzhou 510700, China.
Ruibiao HuBiostime (Changsha) Nutrition Foods Limited, Changsha 410219, China.
Thom HuppertzInternational Joint Research Laboratory for Dairy Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0003-4142-9359
Xinyan WangSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Peng ZhouSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

Funding

Basic Research Program of Jiangsu Province BK20251621Fundamental Research Funds for the Central Universities JUSRP202416004National Key R&D Program of China 2022YFD2101504
6 · The paper itself

Abstract

backgroundLactopontin (L-OPN) is a pivotal bioactive protein present in breast milk that supports bone development, but its efficacy in a formula matrix is unknown. This study aimed to evaluate the effects of L-OPN-fortified formula on bone growth in a growing rat model and to explore the underlying mechanisms.

methodsWeanling rats (

resultsThe results showed that the formula fortified with L-OPN could significantly increase bone volume and trabecular bone number (

conclusionsThese preclinical findings provide a basis for future research in infant formula.

Indexed as

Bone DevelopmentInfant FormulaMilk ProteinsAnimalsBile Acids and SaltsFemaleFemurMaleRatsRats, Sprague-DawleyBile Acids and SaltsMilk Proteinsbile acidbone healthlactopontinParabacteroides

Identifiers

PMID42075077
PMCPMC13118673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.