Evidence map›Paper›PMID 42074903›Full record

ReviewJournal of clinical medicine2026

Evolving Burn Care: The Transition from Life Preservation to Life Restoration-A Narrative Review.

Tobias Niederegger, Jule Brandt, Thomas Schaschinger, Alen Palackic, Valentin Haug, Felix Klimitz, Ulrich Kneser, Christoph Hirche, Benjamin Ziegler, Martin Aman and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tobias NiedereggerMedical Faculty, University of Heidelberg, 69120 Heidelberg, Germany.
Jule BrandtMedical Faculty, University of Heidelberg, 69120 Heidelberg, Germany.
Thomas SchaschingerMedical Faculty, University of Heidelberg, 69120 Heidelberg, Germany.
Alen PalackicDepartment of Hand-, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, 67071 Ludwigshafen, Germany.
Valentin HaugDepartment of Plastic and Reconstructive Surgery, Vivantes Hospital Friedrichshain, 10249 Berlin, Germany.ORCID 0000-0002-2964-979X
Felix KlimitzDepartment of Hand-, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, 67071 Ludwigshafen, Germany.
Ulrich KneserDepartment of Hand-, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, 67071 Ludwigshafen, Germany.ORCID 0000-0002-3402-2860
Christoph HircheDepartment of Plastic Surgery, Hand and Reconstructive Microsurgery, Hand Trauma and Replantation Center (FESSH), BG Unfallklinik Frankfurt, Affiliated Hospital of Goethe University Frankfurt, 60389 Frankfurt, Germany.ORCID 0000-0001-6112-8671
Benjamin ZieglerDepartment of Plastic Surgery, Hand and Reconstructive Microsurgery, Hand Trauma and Replantation Center (FESSH), BG Unfallklinik Frankfurt, Affiliated Hospital of Goethe University Frankfurt, 60389 Frankfurt, Germany.
Martin AmanDepartment of Hand-, Replantation- and Microsurgery, Department of Burns and Plastic Surgery, BG Klinikum Unfallkrankenhaus Berlin, Chair of Hand-, Replantation- and Microsurgery, Charité Universitätsmedizin Berlin, 12683 Berlin, Germany.
Leila Harhaus-WähnerDepartment of Hand-, Replantation- and Microsurgery, Department of Burns and Plastic Surgery, BG Klinikum Unfallkrankenhaus Berlin, Chair of Hand-, Replantation- and Microsurgery, Charité Universitätsmedizin Berlin, 12683 Berlin, Germany.
Gabriel HundeshagenDepartment of Hand-, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, 67071 Ludwigshafen, Germany.ORCID 0000-0002-6173-8602

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past years, burn care has evolved from a discipline focused on survival to one centered on restoring long-term health, function, and quality of life. Significant advances in critical care, early excision and grafting, infection control, and metabolic support have transformed survival outcomes for even the most severe injuries. As a result, the field now faces a new frontier: understanding and managing the long-term physical, psychological, and systemic sequelae of survival. This review traces the evolution of burn care over the last century and outlines the challenges and priorities for the next 25 years. The first era of progress, defined by innovations in resuscitation, surgery, and critical care, has given rise to a growing cohort of long-term survivors. Research over the past decade has revealed that major burns induce chronic multisystem alterations, including metabolic, cardiovascular, neurocognitive, and immunological dysfunctions. Emerging concepts such as burn-associated heart failure exemplify this shift from acute to chronic disease understanding. Looking ahead, the future of burn medicine lies in personalized and lifelong care, supported by translational research, digital health, regenerative therapies, and interdisciplinary collaboration. Overall, burn care stands at a pivotal crossroads. By integrating precision medicine, rehabilitation science, and psychosocial care, we aim to move the field from survival toward sustained, holistic recovery over the next 25 years.

Indexed as

burnburn injuryintensive careorthopedic traumatrauma

Identifiers

PMID42074903
PMCPMC13117504

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.