Evidence map›Paper›PMID 42074684›Full record

ArticleJournal of clinical medicine2026

Effects of Ripasudil Hydrochloride Hydrate-Brimonidine Tartrate Fixed-Dose Combination Using Rho Kinase Inhibitor and Alpha2 Adrenergic Receptor Agonist on Aqueous Column in the Episcleral Vein: A Randomized, Double-Masked, Crossover Clinical Trial (ROCK Alpha-Aqua Study).

Marie Suzuki, Shogo Arimura, Kentaro Iwasaki, Yusuke Orii, Hiroshi Kakimoto, Ryohei Komori, Shigeo Yamamura, Masaru Inatani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marie SuzukiDepartment of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Simoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui 910-0017, Japan.
Shogo ArimuraDepartment of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Simoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui 910-0017, Japan.ORCID 0000-0002-5660-3260
Kentaro IwasakiDepartment of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Simoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui 910-0017, Japan.
Yusuke OriiDepartment of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Simoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui 910-0017, Japan.
Hiroshi KakimotoDepartment of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Simoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui 910-0017, Japan.
Ryohei KomoriDepartment of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Simoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui 910-0017, Japan.ORCID 0000-0002-9575-1266
Shigeo YamamuraThe Faculty of Pharmaceutical Sciences, Josai International University, Gumyo 1, Togane 283-8555, Japan.ORCID 0000-0002-4319-1041
Masaru InataniDepartment of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Simoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui 910-0017, Japan.ORCID 0000-0003-0896-996X

Funding

Kowa Corporation N/A
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

conventional aqueous outflowepiscleral vein aqueous columnhemoglobin video imagingintraocular pressureRho kinase inhibitorripasudil hydrochloride hydrate–brimonidine tartrate fixed-dose combination

Identifiers

PMID42074684
PMCPMC13115889

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.