Evidence map›Paper›PMID 42074578›Full record

ReviewGenes2026

Genomic Landscape, Targeted Therapies, and Mechanisms of Resistance in Molecularly Selected Metastatic Colorectal Cancer Patients.

Patricia Garcia Pastor, Nadia Saoudi González, Francesc Salva, Javier Ros, Iosune Baraibar, Marta Rodríguez Castells, Clara Salva de Torres, Ariadna García, Adriana Alcaraz, Caterina Vaghi and 2 more

Abstract readReview
In one paragraph

Review in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Patricia Garcia PastorMedical Oncology Department, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.
Nadia Saoudi GonzálezMedical Oncology Department, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.
Francesc SalvaMedical Oncology Department, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.ORCID 0000-0001-9240-4907
Javier RosMedical Oncology Department, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.ORCID 0000-0002-8137-5415
Iosune BaraibarMedical Oncology Department, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.ORCID 0000-0002-3500-9641
Marta Rodríguez CastellsMedical Oncology Department, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.ORCID 0000-0003-1935-0951
Clara Salva de TorresMedical Oncology Department, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.
Ariadna GarcíaColorectal Cancer Group, Digestive Tumors Group, Vall d'Hebron Institute of Oncology, VHIO, 08035 Barcelona, Spain.
Adriana AlcarazColorectal Cancer Group, Digestive Tumors Group, Vall d'Hebron Institute of Oncology, VHIO, 08035 Barcelona, Spain.ORCID 0009-0002-5976-3312
Caterina VaghiColorectal Cancer Group, Digestive Tumors Group, Vall d'Hebron Institute of Oncology, VHIO, 08035 Barcelona, Spain.ORCID 0000-0001-5023-3521
Josep TaberneroMedical Oncology Department, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.ORCID 0000-0002-2495-8139
Elena ElezMedical Oncology Department, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastatic colorectal cancer (mCRC) remains one of the leading causes of cancer-related mortality worldwide despite substantial therapeutic improvements over the past two decades. Advances in the understanding of colorectal tumor biology and oncogenic signaling have enabled the development of biomarker-guided therapies targeting alterations in

Indexed as

Colorectal NeoplasmsDrug Resistance, NeoplasmMolecular Targeted TherapyBiomarkers, TumorCirculating Tumor DNAGenomicsHumansMutationNeoplasm MetastasisProto-Oncogene Proteins B-rafBiomarkers, TumorCirculating Tumor DNAProto-Oncogene Proteins B-rafcirculating tumor DNAmetastatic colorectal cancerprecision oncologytargeted therapy

Identifiers

PMID42074578
PMCPMC13116932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.