Evidence map›Paper›PMID 42074523›Full record

ArticleGenes2026

The Necessity of POMC and MC3R Analysis in the First-Level Diagnosis of Monogenic Obesity: The Experience of Two Italian Centers.

Kateryna Miedviedieva, Tommaso Regoli, Stefania Marchisotta, Luca Sessa, Melania Blasco, Silvana Leanza, Cristina Ciuoli, Anna Cantore, Claudia Ricci, Silvia Cantara

Abstract readMulticenter Study
In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kateryna MiedviedievaDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0001-7260-5728
Tommaso RegoliDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.
Stefania MarchisottaSimple Operating Unit of Endocrine Surgery, Ospedale "Il Giglio", 90015 Cefalù, Italy.
Luca SessaSimple Operating Unit of Endocrine Surgery, Ospedale "Il Giglio", 90015 Cefalù, Italy.ORCID 0000-0002-9894-4792
Melania BlascoOperating Unit of Internal Medicine, Ospedale "Il Giglio", 90015 Cefalù, Italy.
Silvana LeanzaSimple Operating Unit of General Surgery, Ospedale "Il Giglio", 90015 Cefalù, Italy.
Cristina CiuoliSimple Operating Departmental Unit of Endocrinology, Ospedale San Donato, 52100 Arezzo, Italy.
Anna CantoreDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.ORCID 0009-0004-6890-3502
Claudia RicciDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-2431-0308
Silvia CantaraDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-5741-295X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesObesity is a global health emergency with a complex etiology, in which monogenic forms, although rare, are significantly underdiagnosed. In our clinical setting, first-tier genetic screening panels targeting

methodsWe analyzed 88 patients with non-syndromic obesity (Body Mass Index, BMI > 30 kg/m

resultsWe found several variants in

conclusionsOur findings demonstrate that expanding first-level routine testing to include

Indexed as

ObesityPro-OpiomelanocortinReceptor, Melanocortin, Type 3AdultBrain-Derived Neurotrophic FactorFemaleGenetic TestingHumansItalyMaleMiddle AgedReceptor, Melanocortin, Type 4Brain-Derived Neurotrophic FactorMC3R protein, humanPro-OpiomelanocortinReceptor, Melanocortin, Type 3Receptor, Melanocortin, Type 4brain-derived neurotrophic factorgeneticlep receptorleptinMelanocortin Receptor 3obesityproopiomelanocortinsingle-nucleotide polymorphisms

Identifiers

PMID42074523
PMCPMC13116659

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.