ArticleGenes2026
Bioinformatics and Preliminary Functional Analysis of OsPP2C61.
Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundProtein phosphatase 2Cs (PP2Cs) constitutes the largest phosphatase family in plants, playing a pivotal role in signal transduction. Within this family, the PP2C.D subfamily exerts significant influence on cell elongation and stress adaptation by mediating the 'SAUR-PP2C.D-H+-ATPase' regulatory module in the auxin signaling pathway. In rice, OsPP2C61 is a PP2C member whose molecular features and potential regulatory context remain unclear.
methodsOur study conducted a preliminary characterization of OsPP2C61 through integrated bioinformatics analysis, spatiotemporal expression profiling, and subcellular localization experiments in tobacco leaf cell.
resultsOsPP2C61 encodes a 377-amino-acid protein predicted to be hydrophilic, basic, and structurally unstable. Secondary-structure prediction identified three major elements with random coils as the predominant component, whereas 3D modeling indicated alternating α-helices and β-sheets consistent with a canonical PP2C fold. Phylogenetic inference placed OsPP2C61 within the PP2C.D clade and revealed conserved motifs shared with OsPP2C25, OsPP2C28, and OsPP2C39. Promoter analysis showed enrichment of abscisic acid (ABA)- and methyl jasmonate (MeJA)-responsive elements along with multiple stress-related cis-regulatory motifs. Spatiotemporal expression analysis showed that OsPP2C61 is highly expressed in roots. Subcellular localization assays further demonstrated that the OsPP2C61-GFP fusion protein localizes to the nucleus and the plasma membrane when transiently expressed in epidermal cells of
conclusionsThis work delivers the first comprehensive characterization of OsPP2C61, establishing a foundation for mechanistic studies and positioning OsPP2C61 as a candidate gene for rice improvement.
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