Evidence map›Paper›PMID 42074425›Full record

Observational studyInternational journal of environmental research and public health2026

Frailty Through a One Health Lens: Biological Sex, Mental Health, and Oral Function in Physically Active Older Adults.

Luciano Maia Alves Ferreira, José Brito, Catarina Colaço, Marcelo Palinkas, Ricardo Brites, Maia E Maia Fischel E Andrade, João Tiago Botelho, José João Baltazar Mendes, Selma Siessere, Simone Regalo

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of environmental research and public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Luciano Maia Alves FerreiraMathias Vitti Electromyography Laboratory, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0001-7536-9193
José BritoClinical Research Unit (CRU), Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Almada, Portugal.
Catarina ColaçoClinical Research Unit (CRU), Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Almada, Portugal.ORCID 0009-0009-1446-0036
Marcelo PalinkasMathias Vitti Electromyography Laboratory, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-3445-8154
Ricardo BritesNeuromodulation and Pain Laboratory (NEUROPAIN), Egas Moniz School of Health & Science, 2829-511 Almada, Portugal.ORCID 0009-0000-0871-4698
Maia E Maia Fischel E AndradeLaboratory of Neuroscience, Neuromodulation and Study of Pain (LANNED), Federal University of Alfenas (UNIFAL-MG), Alfenas 37130-001, Brazil.ORCID 0009-0008-6867-4390
João Tiago BotelhoClinical Research Unit (CRU), Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Almada, Portugal.ORCID 0000-0002-1019-8263
José João Baltazar MendesClinical Research Unit (CRU), Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Almada, Portugal.ORCID 0000-0003-0167-4077
Selma SiessereMathias Vitti Electromyography Laboratory, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0001-9756-3771
Simone RegaloMathias Vitti Electromyography Laboratory, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0003-4110-8299

Funding

FCT-Foundation for Science and Technology, I.P. UIDB/04585/2020
6 · The paper itself

Abstract

Frailty is a multifactorial geriatric syndrome marked by reduced physiological reserves and increased vulnerability to adverse outcomes. This multicenter observational study adopted a One Health approach to examine the association between frailty and biological sex, denture use, and antidepressant medication, as well as their impact on bite force, in two transnational cohorts of physically active older adults. The sample included 499 individuals aged ≥60 years (295 from Brazil and 204 from Portugal), all with functional dentition and regular physical activity. Frailty was assessed using the adapted Fried phenotype and classified as non-frail (G0), pre-frail (G1), or frail (G2). Oral health, depressive symptoms (CES-D), bite force, and self-reported use of dentures and antidepressants were analyzed. Frailty was significantly associated with biological sex (

Indexed as

ExerciseFrail ElderlyFrailtyMental HealthOral HealthAgedAged, 80 and overAntidepressive AgentsBite ForceBrazilDenturesDepressionFemaleHumansMaleMiddle AgedAntidepressive Agentsagingfrailtygeriatric assessmenthealth of the older adultsprimary care

Identifiers

PMID42074425
PMCPMC13115621

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.