Evidence map›Paper›PMID 42074405›Full record

ArticleInternational journal of environmental research and public health2026

Long-Term Epidemiological Trends and Regional Disparities in Male Infertility in Central Asia (1991-2023).

Mukhamediyar Mukhamejan, Timur Shamshudinov, Mirzakarim Alchinbayev, Nariman Tabynbayev, Murat Dursun, Assiya Kussainova, Laura Kassym, Oxana Tsigengagel, Nurbolat Zhambylov, Yuliya Semenova

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Article in International journal of environmental research and public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Mukhamediyar MukhamejanDepartment of Urology and Andrology, Kazakh National Medical University Named After S.D. Asfendiyarov, Almaty 050054, Kazakhstan.
Timur ShamshudinovMedical and Diagnostic Center of Otorhinolaryngology, Almaty 050026, Kazakhstan.
Mirzakarim AlchinbayevDepartment of Urology and Andrology, Kazakh National Medical University Named After S.D. Asfendiyarov, Almaty 050054, Kazakhstan.
Nariman TabynbayevDepartment of Urology and Andrology, Kazakh National Medical University Named After S.D. Asfendiyarov, Almaty 050054, Kazakhstan.
Murat DursunDepartment of Urology (Istanbul Medical Faculty), Istanbul University, Istanbul 3445, Turkey.
Assiya KussainovaDepartment of General Medical Practice with a Course of Evidence-Based Medicine, NJSC "Astana Medical University", Astana 010000, Kazakhstan.
Laura KassymDepartment of General Medical Practice with a Course of Evidence-Based Medicine, NJSC "Astana Medical University", Astana 010000, Kazakhstan.
Oxana TsigengagelDepartment of Epidemiology and Biostatistics, NJSC "Astana Medical University", Astana 010000, Kazakhstan.
Nurbolat ZhambylovDepartment of Urology and Andrology, Kazakh National Medical University Named After S.D. Asfendiyarov, Almaty 050054, Kazakhstan.
Yuliya SemenovaSchool of Medicine, Nazarbayev University, Astana 010000, Kazakhstan.ORCID 0000-0003-1324-7806

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMale infertility (MI) has become an important public health concern in Central Asia (CA), where declining fertility coincides with limited integration of male reproductive health into national strategies. This study analyzed trends in the prevalence and burden of MI in CA countries and assessed associations with selected modifiable behavioral risk factors.

methodsA longitudinal analysis of Global Burden of Disease (GBD) 2023 data was conducted to estimate the age-standardized prevalence and incidence of MI among men aged 15-49 years in five CA countries from 1990 to 2023. Trends were examined, and fixed-effects panel regression models were applied to evaluate associations between MI burden and alcohol use, drug use, and sexually transmitted infections (excluding HIV).

resultsFrom 1991 to 2023, the age-standardized prevalence increased in four CA countries, whereas Tajikistan showed a decline; the incidence rose across all countries. The peak incidence was most commonly observed at ages 35-39 years, although Tajikistan shifted toward a younger age group, and regression analyses revealed heterogeneous country-specific associations with sociobehavioral risk factors.

conclusionsMI represents a significant demographic and public health challenge in CA, highlighting the need to strengthen surveillance, standardize diagnostics, improve access to care, and integrate male reproductive health into national prevention strategies.

Indexed as

Infertility, MaleAdolescentAdultAsia, CentralHumansIncidenceLongitudinal StudiesMaleMiddle AgedPrevalenceRisk FactorsYoung Adultalcohol useCentral Asiadrug usemale infertilitysociobehavioral determinantsSTIs

Identifiers

PMID42074405
PMCPMC13116784

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.