Evidence map›Paper›PMID 42074298›Full record

ArticleInternational journal of molecular sciences2026

Time- and Dose-Dependent PSP-Induced Modulation of Antiviral Signaling Networks in CD4+ T Cells.

Glamaris N Rosario-Sanfiorenzo, Giovanni O Alicea-Pérez, Ashlin N Álvarez-Flores, Naiara I Hernández-Santisteban, Amanda C Rivera-Payán, Jeshua J Colón-Fernández, Abigail M Rivera-Berganzo, Victoria Bermudez-Fosse, Ileanmarie Santana-Costas, Carolina Nieves-Moreno and 6 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Glamaris N Rosario-SanfiorenzoDepartment of Science and Technology, Interamerican University of Puerto Rico, Metropolitan Campus, San Juan, PR 00926, USA.ORCID 0009-0001-6664-0129
Giovanni O Alicea-PérezDepartment of Biology, Universidad de Puerto Rico, Bayamón, PR 00960, USA.ORCID 0009-0008-8667-831X
Ashlin N Álvarez-FloresDepartment of Biology, Universidad de Puerto Rico, Arecibo, PR 00612, USA.ORCID 0009-0007-9659-4825
Naiara I Hernández-SantistebanDepartment of Science and Technology, Interamerican University of Puerto Rico, Metropolitan Campus, San Juan, PR 00926, USA.
Amanda C Rivera-PayánDepartment of Science and Technology, Interamerican University of Puerto Rico, Metropolitan Campus, San Juan, PR 00926, USA.ORCID 0009-0007-7180-9033
Jeshua J Colón-FernándezDepartment of Science and Technology, Interamerican University of Puerto Rico, Metropolitan Campus, San Juan, PR 00926, USA.
Abigail M Rivera-BerganzoDepartment of Science and Technology, Interamerican University of Puerto Rico, Metropolitan Campus, San Juan, PR 00926, USA.
Victoria Bermudez-FosseSchool of Medicine, Universidad Central del Caribe, Bayamón, PR 00960, USA.
Ileanmarie Santana-CostasJames L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45221, USA.
Carolina Nieves-MorenoDepartment of Biology, Universidad de Puerto Rico, Arecibo, PR 00612, USA.ORCID 0009-0000-1677-5204
Fabiola I Colón-SantiagoSchool of Medicine, Universidad Central del Caribe, Bayamón, PR 00960, USA.
Julieness M Correa-HaifaDepartment of Biology, Universidad de Puerto Rico, Bayamón, PR 00960, USA.
Natalia I Sánchez-OteroDepartment of Science and Technology, Interamerican University of Puerto Rico, Metropolitan Campus, San Juan, PR 00926, USA.
Geraldine Cintrón-VélezDepartment of Biology, Universidad de Puerto Rico, Río Piedras, PR 00925, USA.
Génesis M Matos-MoralesDepartment of Science and Technology, Interamerican University of Puerto Rico, Metropolitan Campus, San Juan, PR 00926, USA.
Eduardo Álvarez-RiveraDepartment of Microbiology and Immunology, School of Medicine, Universidad Central del Caribe, Bayamón, PR 00960, USA.ORCID 0000-0002-5782-6490

Funding

Hispanic Alliance for Clinical and Translational Research 2P50GM133807University of Puerto - Medical Science Campus PO31S200104
6 · The paper itself

Abstract

Natural bioactive polysaccharides have been investigated for their ability to modulate antiviral immune responses. Polysaccharide peptide (PSP) from

Indexed as

Antiviral AgentsCD4-Positive T-LymphocytesPolysaccharidesSignal TransductionCell SurvivaleIF-2 KinaseHIV-1HumansInterferon-gammaJurkat CellsNF-kappa BToll-Like Receptor 4Antiviral AgentseIF-2 KinaseInterferon-gammaNF-kappa BPolysaccharidesToll-Like Receptor 4cofilin-1Coriolus versicolorinterferonJurkat T cellsnuclear factor kappa Bpolysaccharide peptideprotein kinase Rsignal transducer and activator of transcriptiontoll-like receptor 4

Identifiers

PMID42074298
PMCPMC13115976

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.