Evidence map›Paper›PMID 42074297›Full record

ArticleInternational journal of molecular sciences2026

Glycosyl Coumarins as Selective Inhibitors of Tumor-Associated Carbonic Anhydrase IX and XII: Synthesis, Structure-Activity Relationships, and Molecular Modeling.

Macarena S Le Pors, Ignacio Aznar, Simone Giovannuzzi, Claudiu T Supuran, Martin J Lavecchia, Pedro A Colinas

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Macarena S Le PorsCEDECOR (UNLP-CICBA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, La Plata 1900, Argentina.
Ignacio AznarCEDECOR (UNLP-CICBA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, La Plata 1900, Argentina.
Simone GiovannuzziSection of Pharmaceutical Chemistry, NEUROFARBA Department, Università Degli Studi di Firenze, via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0000-0002-0669-7481
Claudiu T SupuranSection of Pharmaceutical Chemistry, NEUROFARBA Department, Università Degli Studi di Firenze, via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0000-0003-4262-0323
Martin J LavecchiaCEQUINOR (UNLP-CONICET, CCT-La Plata, Associated with CIC), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata Blvd. 120, La Plata 1465, Argentina.ORCID 0000-0001-8678-4237
Pedro A ColinasCEDECOR (UNLP-CICBA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, La Plata 1900, Argentina.ORCID 0000-0001-7688-3063

Funding

Consejo Nacional de Investigaciones Científicas y Técnicas PIP1695Universidad Nacional de La Plata 11X/927, 11/X958
6 · The paper itself

Abstract

Coumarins represent a distinctive class of non-classical carbonic anhydrase inhibitors that interact with the entrance region of the catalytic pocket rather than directly coordinating the catalytic Zn

Indexed as

Carbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic AnhydrasesCoumarinsAntigens, NeoplasmHumansModels, MolecularMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity RelationshipAntigens, NeoplasmCA9 protein, humanCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic Anhydrasescarbonic anhydrase XIICoumarinsanticancer agentscarbohydratesmolecular dynamics simulations

Identifiers

PMID42074297
PMCPMC13116586

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.