Evidence map›Paper›PMID 42074277›Full record

ArticleInternational journal of molecular sciences2026

Alb-PRF Hybrid Membranes Functionalized with Carbonated Hydroxyapatite and Doxycycline for Bone Regeneration and Antimicrobial Control: An In Vitro Study.

Neilane Rodrigues Santiago Rocha, Emanuelle Stellet Lourenço, Victor Hugo de Souza Lima, Carlos Alberto Soriano, Alexandre Malta Rossi, Carolina N Spiegel, Monica Diuana Calasans-Maia, Carlos Fernando Mourão, Gutemberg Gomes Alves

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Neilane Rodrigues Santiago RochaGraduate Program in Science and Biotechnology, Fluminense Federal University, Niteroi 24210-201, Brazil.ORCID 0009-0009-2358-0064
Emanuelle Stellet LourençoOral Surgery Department, Dental School, Fluminense Federal University, Rio de Janeiro 24020-140, Brazil.
Victor Hugo de Souza LimaGraduate Program in Science and Biotechnology, Fluminense Federal University, Niteroi 24210-201, Brazil.
Carlos Alberto SorianoDepartment of Condensed Matter, Applied Physics and Nanoscience, Brazilian Center for Research in Physics, Rio de Janeiro 22290-180, Brazil.
Alexandre Malta RossiDepartment of Condensed Matter, Applied Physics and Nanoscience, Brazilian Center for Research in Physics, Rio de Janeiro 22290-180, Brazil.
Carolina N SpiegelDepartment of Cellular and Molecular Biology, Fluminense Federal University, Niteroi 24033-900, Brazil.ORCID 0000-0003-3291-9903
Monica Diuana Calasans-MaiaOral Surgery Department, Dental School, Fluminense Federal University, Rio de Janeiro 24020-140, Brazil.ORCID 0000-0001-5759-7926
Carlos Fernando MourãoDepartment of Basic & Clinical Translational Sciences, Tufts University School of Dental Medicine, Boston, MA 02111, USA.ORCID 0000-0001-5775-0222
Gutemberg Gomes AlvesDepartment of Cellular and Molecular Biology, Fluminense Federal University, Niteroi 24033-900, Brazil.ORCID 0000-0003-0016-4809

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone tissue engineering requires biomaterials capable of simultaneously supporting regeneration and preventing infection. Platelet-rich fibrin (PRF) has been widely used due to its autologous origin and growth factor release, but its rapid resorption limits its clinical applications. Albumin-PRF (Alb-PRF) membranes were developed to improve stability, and their combination with carbonated nanostructured hydroxyapatite (nCHA) may further reinforce osteoconductive properties. In this proof-of-concept study, we fabricated Alb-PRF, Alb-nCHA-PRF, and Alb-nCHA-PRF + doxycycline (DOX) membranes and characterized their physicochemical, antimicrobial, and biological performance in vitro. Membrane stability was monitored for up to 14 days; DOX incorporation and release were evaluated by autofluorescence and spectrophotometry; antimicrobial activity was assessed against

Indexed as

AlbuminsBlood PlateletsBone RegenerationDoxycyclineDurapatiteFibrinAnti-Bacterial AgentsBiocompatible MaterialsCell LineCell ProliferationEnterococcus faecalisHumansMembranes, ArtificialOsteoblastsStaphylococcus aureusAlbuminsAnti-Bacterial AgentsBiocompatible MaterialsDoxycyclineDurapatiteFibrinMembranes, Artificialalbumin-PRFantimicrobial biomaterialbone regenerationdoxycyclinehydroxyapatite

Identifiers

PMID42074277
PMCPMC13115618

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.