Evidence map›Paper›PMID 42074210›Full record

ArticleInternational journal of molecular sciences2026

Administration of Topical NorLeu

Catherine Chester, Edgar Alejandro Moreno-Diaz, Weiyuan Hu, Brianna Chen, Maram Alshammari, Mark S Humayun, Juan Carlos Martinez Camarillo, Stan G Louie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Catherine ChesterTitus Family Department of Clinical Pharmacy, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Edgar Alejandro Moreno-DiazRoski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0003-1283-1744
Weiyuan HuTitus Family Department of Clinical Pharmacy, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Brianna ChenTitus Family Department of Clinical Pharmacy, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Maram AlshammariTitus Family Department of Clinical Pharmacy, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Mark S HumayunRoski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Juan Carlos Martinez CamarilloRoski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Stan G LouieTitus Family Department of Clinical Pharmacy, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0001-5941-6690

Funding

United States Department of Defense W81XWH2110740
6 · The paper itself

Abstract

Severe full-thickness corneal lacerations disrupt the tight cellular and extracellular matrix (ECM) organization required for corneal transparency. Following injury, an influx of transforming growth factor beta (TGFβ) into the corneal stroma signals the formation of haze-inducing myofibroblasts, resulting in excessive stromal remodeling and corneal haze. We hypothesized that MasR activation using NorLeu

Indexed as

CorneaCorneal InjuriesPeptide FragmentsWound HealingAdministration, TopicalAngiotensin IAnimalsFibrosisMaleMyofibroblastsRabbitsTransforming Growth Factor betaAngiotensin Iangiotensin I (1-7)Peptide FragmentsTransforming Growth Factor betacorneacorneal hazecorneal repairfibrosisMasRmyofibroblastrenin–angiotensin system

Identifiers

PMID42074210
PMCPMC13115795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.