Evidence map›Paper›PMID 42074186›Full record

ArticleInternational journal of molecular sciences2026

Molecular and Functional Alterations of P-Glycoprotein in a Genetic Model of Epilepsy: Insights from the Wistar Audiogenic Rat.

Rodrigo V Placido, Rafaela F Rodrigues, Lellis H Costa, Taila Kawano, Milton K Aquino, Gabriella B Martinez, Mariana T R Hummel, Maria Eduarda T de Lima, Rui M P da Silva, Norberto Garcia-Cairasco and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rodrigo V PlacidoPharmaceutical Sciences Faculty, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil.
Rafaela F RodriguesPharmaceutical Sciences Faculty, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil.
Lellis H CostaPharmaceutical Sciences Faculty, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil.
Taila KawanoPharmaceutical Sciences Faculty, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil.
Milton K AquinoPharmaceutical Sciences Faculty, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil.
Gabriella B MartinezPharmaceutical Sciences Faculty, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil.
Mariana T R HummelPharmaceutical Sciences Faculty, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil.
Maria Eduarda T de LimaPharmaceutical Sciences Faculty, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil.
Rui M P da SilvaNeurophysiology and Experimental Neuroethology Laboratory, Department of Physiology, University of São Paulo, Ribeirão Preto 05508-220, SP, Brazil.
Norberto Garcia-CairascoNeurophysiology and Experimental Neuroethology Laboratory, Department of Physiology, University of São Paulo, Ribeirão Preto 05508-220, SP, Brazil.ORCID 0000-0001-8857-3775
Silvia G RuginskInstitute of Biomedical Sciences, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil.ORCID 0000-0002-0534-0077
Marília G A G PereiraInstitute of Biomedical Sciences, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil.ORCID 0000-0002-0894-954X
Vanessa B BoralliPharmaceutical Sciences Faculty, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil.ORCID 0000-0002-7033-0350

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-00544-23Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-05218-23
6 · The paper itself

Abstract

Drug resistance remains a major challenge in epilepsy, and overexpression of ATP-binding cassette transporters, particularly P-glycoprotein (P-gp), at the blood-brain barrier (BBB) has been consistently implicated in limiting central nervous system drug exposure. Genetic experimental models suitable for investigating molecular regulation and functional alterations of P-gp in epilepsy remain scarce. This study evaluated P-gp expression and functional alterations in the Wistar Audiogenic Rat (WAR), a genetic model of epilepsy exhibiting phenotypic heterogeneity. WAR animals were classified into refractory epilepsy (WAR-RE) or temporal lobe epilepsy (WAR-TLE) phenotypes and compared with non-epileptic Wistar controls. Fexofenadine, a well-established in vivo P-gp probe substrate, was administered orally, and plasma pharmacokinetic parameters were determined. P-gp expression at the BBB was assessed by immunohistochemistry in hippocampal regions. WAR-RE animals exhibited significantly increased systemic exposure to fexofenadine, characterized by higher area under the curve and prolonged half-life, alongside reduced apparent clearance, compared with control animals (

Indexed as

ATP Binding Cassette Transporter, Subfamily B, Member 1EpilepsyEpilepsy, ReflexAnimalsBlood-Brain BarrierDisease Models, AnimalHippocampusMaleRatsRats, WistarTerfenadineATP Binding Cassette Transporter, Subfamily B, Member 1fexofenadineTerfenadineATP binding cassette transporterdrug resistancedrug resistant epilepsyepilepsymember 1pharmacokineticssubfamily B

Identifiers

PMID42074186
PMCPMC13115665

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.