ArticleInternational journal of molecular sciences2026
In Silico Perturbation Identifies Transcription Factors as Protective Targets in HSPCs After Irradiation.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hematopoietic stem and progenitor cells (HSPCs) in the bone marrow are highly vulnerable to radiation-induced damage. Systematic delineation of lineage-specific transcription factor (TF) programs, together with in silico perturbation analyses, provides a valuable approach for identifying regulators capable of accelerating hematopoietic reconstruction after irradiation. Here, using single-cell RNA sequencing (scRNA-seq), we characterized the dynamics of HSPCs at both cellular abundance and transcriptional regulation levels following irradiation and used in silico TF perturbation to predict their effects on lineage commitment. We found that granulocyte-macrophage progenitor (GMP) differentiation is consistently prioritized after irradiation, accompanied by enhanced activity of proliferation-associated drivers. Network-based TF profiling identified
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