ArticleInternational journal of molecular sciences2026
Bimodal Fluorescent Conjugate Based on Prostate-Specific Membrane Antigen Ligands with the Chelating Agent DOTA and SulfoCy5 Dye: Synthesis, Radiolabeling, and Biological Activity.
Aleksei E Machulkin, Stanislav A Petrov, Nina S Butakova, Aleksandr S Lunev, Kristina A Petrosova, Radik R Shafikov, Dmitry A Skvortsov, Iurii A Mitrofanov, Mariia N Ivashkovaskaia, Elena K Beloglazkina and 1 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
11 authors.
Aleksei E MachulkinChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia.ORCID 0000-0001-7975-0346 Stanislav A PetrovChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia.ORCID 0000-0002-6000-6100 Nina S ButakovaChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia.
Aleksandr S LunevFSBI State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 123098 Moscow, Russia.
Kristina A PetrosovaFSBI State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 123098 Moscow, Russia.ORCID 0000-0002-1256-9873 Radik R ShafikovChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia.ORCID 0000-0002-9349-5211 Dmitry A SkvortsovChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia.
Iurii A MitrofanovFSBI State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 123098 Moscow, Russia.ORCID 0000-0001-5249-8507 Mariia N IvashkovaskaiaFSBI State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 123098 Moscow, Russia.ORCID 0009-0008-6026-0329 Elena K BeloglazkinaChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia.ORCID 0000-0001-6796-8241 Anton A LarenkovFSBI State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 123098 Moscow, Russia.ORCID 0000-0003-4810-4346 Funding
Russian Science Foundation 22-15-00098-P
6 · The paper itselfAbstract
Prostate-specific membrane antigen (PSMA) is an essential zinc-dependent metalloprotease classified within the type II transmembrane protein family, often referred to as glutamate carboxypeptidase II (GCPII). PSMA is recognized as a particularly promising target for both the diagnosis and therapeutic intervention of prostate cancer. In this study, we designed and synthesized PSMA-targeted DOTA-loaded bimodal conjugate
Indexed as
Antigens, SurfaceCarbocyaninesChelating AgentsFluorescent DyesGlutamate Carboxypeptidase IIHeterocyclic Compounds, 1-RingProstatic NeoplasmsRadiopharmaceuticalsAnimalsCell Line, TumorGallium RadioisotopesHumansLigandsMaleMicePositron-Emission Tomography1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidAntigens, SurfaceCarbocyaninesChelating AgentsFluorescent DyesFOLH1 protein, humanGallium RadioisotopesGlutamate Carboxypeptidase IIHeterocyclic Compounds, 1-RingLigandsRadiopharmaceuticalsbimodal conjugatesDOTA-conjugatesdrug deliveryprostate cancerPSMA
Identifiers
PMID42074146
PMCPMC13116809
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