Evidence map›Paper›PMID 42074140›Full record

ReviewInternational journal of molecular sciences2026

Epithelial Integrins Coordinate Cellular Crosstalk Through the Regulation of Cytokines During Tissue Remodeling.

Jacob Snyder, Sanjana Dhulipalla, Whitney M Longmate

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jacob SnyderDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY 12208, USA.ORCID 0009-0009-0933-182X
Sanjana DhulipallaDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY 12208, USA.ORCID 0009-0009-7563-3594
Whitney M LongmateDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY 12208, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Integrins are obligate αβ heterodimeric receptors that mediate cell-extracellular matrix interactions and exhibit bidirectional signal transduction across the plasma membrane. This integrin-mediated signal transduction regulates the expression of genes, a subset of which encode cytokines-small, secreted proteins that exhibit cell-cell communication in an autocrine or paracrine manner to regulate cell survival, proliferation, migration, ECM remodeling, and the immune response. This review examines epithelial integrins in the regulation of paracrine-acting cytokines that crosstalk to immune and stromal cells to coordinate normal and pathological tissue remodeling. Contexts explored include wound repair, fibrosis, and cancer.

Indexed as

CytokinesEpithelial CellsIntegrinsAnimalsCarcinogenesisCellular MicroenvironmentFibrosisHumansParacrine CommunicationReceptor Cross-TalkSignal TransductionWound HealingCytokinesIntegrinscrosstalkcytokinesextracellular matrixfibrosisintegrinssecretometumor microenvironmentwound healing

Identifiers

PMID42074140
PMCPMC13115989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.