Evidence map›Paper›PMID 42074095›Full record

ArticleInternational journal of molecular sciences2026

Respiratory Models Reveal DNA Damage Response Modulation by Merkel Cell Polyomavirus.

Sara Passerini, Marta De Angelis, Sara Messina, Daniela Scribano, Cecilia Ambrosi, Ugo Moens, Lucia Nencioni, Valeria Pietropaolo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sara PasseriniDepartment of Public Health and Infectious Diseases, Sapienza University, 00185 Rome, Italy.ORCID 0000-0002-0678-5537
Marta De AngelisDepartment of Public Health and Infectious Diseases, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University, 00185 Rome, Italy.ORCID 0000-0002-1916-6508
Sara MessinaDepartment of Public Health and Infectious Diseases, Sapienza University, 00185 Rome, Italy.ORCID 0009-0000-6640-9683
Daniela ScribanoDepartment of Public Health and Infectious Diseases, Sapienza University, 00185 Rome, Italy.ORCID 0000-0002-2901-265X
Cecilia AmbrosiLaboratory of Microbiology, IRCCS San Raffaele Roma, 00143 Rome, Italy.ORCID 0000-0003-2163-1613
Ugo MoensDepartment of Medical Biology, Faculty of Health Sciences, UiT-The Arctic University of Norway, 9037 Tromsø, Norway.
Lucia NencioniDepartment of Public Health and Infectious Diseases, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University, 00185 Rome, Italy.ORCID 0000-0003-4427-4823
Valeria PietropaoloDepartment of Public Health and Infectious Diseases, Sapienza University, 00185 Rome, Italy.ORCID 0000-0001-5723-8886

Funding

Ministero dell'Istruzione e del Merito 2022FRE3RHMinistero dell'Istruzione e del Merito RP124190255A2CB7Ministero dell'Istruzione e del Merito RP125199A48F33A6
6 · The paper itself

Abstract

Merkel Cell Polyomavirus is an oncogenic virus associated with Merkel Cell Carcinoma (MCC). However, considering viral detection in respiratory specimens and similarities between MCC and neuroendocrine lung cancer, its plausible role in the respiratory tract is disputed. MCPyV-mediated oncogenesis involves viral antigens interfering with host signaling as a DNA Damage Response (DDR). In the current study, respiratory models, including lung cancer cell lines (A549 and H1299), and non-malignant bronchial systems (HBEC-KT and a 2D ALI model) were used to investigate DDR genes' expression following MCPyV infection. Once the capability to support viral replication and transcription was assessed using qPCR and RT-qPCR, respectively, the mRNA levels of DDR genes, including

Indexed as

Carcinoma, Merkel CellDNA DamageMerkel cell polyomavirusPolyomavirus InfectionsCell Line, TumorDNA, ViralHumansVirus ReplicationDNA, ViralDNA Damage ResponseMerkel Cell Polyomavirusoncogenesisrespiratory modelstranscriptional level

Identifiers

PMID42074095
PMCPMC13116865

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.