Evidence map›Paper›PMID 42074054›Full record

ArticleInternational journal of molecular sciences2026

Fe(II) with Tris(1-pyrazolyl)methane Complex Increases Thermal Stability In Vitro and Activity In Vivo of the Mutant 447R Form of Mouse Tryptophan Hydroxylase 2.

Ekatherine I Terentieva, Polina D Komleva, Sophia M Antonova, Vitalii S Moskaliuk, Nikita V Khotskin, Maxim V Shamshurin, Maxim N Sokolov, Alexander V Kulikov

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ekatherine I TerentievaThe Federal Research Center Institute Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.
Polina D KomlevaThe Federal Research Center Institute Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.ORCID 0009-0004-0048-2158
Sophia M AntonovaThe Federal Research Center Institute Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.
Vitalii S MoskaliukThe Federal Research Center Institute Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.
Nikita V KhotskinThe Federal Research Center Institute Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.
Maxim V ShamshurinNikolaev Institute of Inorganic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.
Maxim N SokolovNikolaev Institute of Inorganic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.ORCID 0000-0001-9361-4594
Alexander V KulikovThe Federal Research Center Institute Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.ORCID 0000-0003-3816-6244

Funding

Russian Foundation for Basic Research 24-15-00078
6 · The paper itself

Abstract

Pharmacological chaperones (PCs)-small molecules that normalize the 3D structure of mutant protein molecules-are promising substances for pharmacological treatment of grave hereditary pathologies. In this study, possible chaperone-like effects of the Fe(II) with tris(1-pyrasolyl)methane complex, [Fe(TPM)

Indexed as

Ferrous CompoundsMutationPyrazolesTryptophan HydroxylaseAnimalsEnzyme StabilityMaleMiceMice, Inbred BALB CFerrous CompoundsPyrazolesTph2 protein, mouseTryptophan HydroxylaseactivitybrainFe(II) tris(1-pyrazolyl)methane complexmicethermal stabilitytryptophan hydroxylase 2

Identifiers

PMID42074054
PMCPMC13115991

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.