ReviewInternational journal of molecular sciences2026
Multiple Regulatory Mechanisms of Post-Translational Modifications and Therapeutic Potential of Mitotic Catastrophe.
Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Mitotic catastrophe refers to a complicated mechanism of cell death characterized by failure to complete the processes of mitosis correctly due to aberrant chromosome segregation and abnormal tubulin polymerization. Post-translational modifications (PTMs) play a crucial role in the functional diversity of the proteome by mediating the covalent attachment of functional groups to proteins, which regulates the proteolytic cleavage of subunits, facilitating the degradation of entire proteins. Recent studies suggest that PTMs of key proteins are closely implicated in the occurrence, regulation and potential therapeutic targets of mitotic catastrophe. Here, we summarize how multiple PTMs, including phosphorylation, ubiquitination, acetylation, methylation and other types of PTMs, regulate mitotic catastrophe. In addition, potential therapeutic approaches targeting mitotic catastrophe were also discussed. It is anticipated that the inducement of mitotic catastrophe can serve as a promising new therapeutic approach for various diseases in the future.
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