ReviewBehavioral sciences (Basel, Switzerland)2026
Early Adverse Experiences and the Likelihood of Substance Use Disorders and Non-Fatal Overdose in Clinical and Community Settings: A Systematic Review and Meta-Analysis.
Review in Behavioral sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early adverse experiences may increase the likelihood of substance use disorders/addictions (SUD) and overdose, but estimates vary across settings. This review synthesised observational evidence on early adverse experiences and disorder-level SUD outcomes and/or non-fatal overdose. PubMed, Scopus, Web of Science, ScienceDirect, SpringerLink, and Taylor & Francis were searched up until 1 December 2025. Eligible observational studies sampled psychiatric treatment or community populations, measured early adverse experiences, and reported associations with disorder-level SUD/addiction or non-fatal overdose. Risk of bias was assessed using Joanna Briggs Institute (JBI) tools. A random-effects meta-analysis pooled commensurate overdose estimates; the remaining evidence was synthesised narratively. Nine studies were included (n = 67,228 participants; one cohort did not report an analytic sample size). SUD associations were consistently positive (adjusted odds ratio (OR) range 1.71-4.30) but were not pooled due to heterogeneity in exposure and outcome definitions. Three studies (721 participants) contributed to the overdose meta-analysis; a higher adverse childhood experience (ACE) score was associated with higher odds of non-fatal overdose (pooled OR 1.16 per +1 ACE, 95% confidence interval (CI) 1.06-1.28; I
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