Evidence map›Paper›PMID 42073574›Full record

ArticleCancers2026

Histotripsy-Initiated Immune Response Synergizes with Chemotherapy in a Neuroblastoma Murine Model.

Natalia Antonides-Jensen, Muskan Singh, Yuqing Xue, Fernando Flores-Guzman, Lydia L Wu, Samantha S Yee, Jacky Gomez-Villa, Timothy L Hall, Mark A Applebaum, Kenneth B Bader and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Histotripsy for Liver Tumors: Breakthrough or Hype?Annals of surgical oncology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Natalia Antonides-JensenDepartment of Radiology, University of Chicago, Chicago, IL 60637, USA.
Muskan SinghDepartment of Radiology, University of Chicago, Chicago, IL 60637, USA.
Yuqing XueDepartment of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-8909-0270
Fernando Flores-GuzmanDepartment of Surgery, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-2148-6196
Lydia L WuDepartment of Surgery, University of Chicago, Chicago, IL 60637, USA.
Samantha S YeeDepartment of Surgery, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-7953-0183
Jacky Gomez-VillaDepartment of Surgery, University of Chicago, Chicago, IL 60637, USA.
Timothy L HallDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Mark A ApplebaumDepartment of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-9766-8477
Kenneth B BaderDepartment of Radiology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-2384-3150
Sonia L HernandezDepartment of Surgery, University of Chicago, Chicago, IL 60637, USA.

Funding

American Cancer Society RSG-21-171-01-ETNIH HHS R01 EB0352309
6 · The paper itself

Abstract

backgroundHigh-risk neuroblastoma (NB) is a pediatric malignancy associated with metastases and an immunosuppressive tumor microenvironment. Standard-of-care treatments like chemotherapy are often ineffective, which motivates the investigation of adjuvant approaches. Histotripsy is a noninvasive focused ultrasound therapy that ablates tissue through the mechanical action of bubble clouds. In addition to disruption of the targeted tumor, non-targeted lesions may exhibit growth delay after the histotripsy procedure. The primary hypothesis of this study was histotripsy-induced shifts in the tumor microenvironment will improve the response of metastatic NB to chemotherapy.

methodsFemale A/J mice flanks were inoculated bilaterally with 1 × 10

resultsHistotripsy alone delayed the growth of treated and contralateral tumors relative to controls (

conclusionsThese findings indicate that histotripsy induces a systemic antitumor immune response that potentiates chemotherapy efficacy in this model of metastatic NB.

Indexed as

abscopal effectchemotherapy potentiationhistotripsyneuroblastomatumor microenvironment

Identifiers

PMID42073574
PMCPMC13114721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.