Evidence map›Paper›PMID 42073502›Full record

ArticleLife (Basel, Switzerland)2026

Effect of Lateralization, Age, and Sex on Frequency Following Response in Children: Neural Speech Encoding to a 170 ms [da] Stimulus.

Caroline Donadon, Milaine Dominici Sanfins, Aline Buratti Sanches, Gabriele Libano de Souza Cardoso, Ayla Gabrielle Paschoalon de Mello, Piotr Henryk Skarzynski, Maria Francisca Colella-Santos

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Caroline DonadonGraduate Program in Child and Adolescent Health, Faculty of Medical Sciences, State University of Campinas, Campinas 13083-887, SP, Brazil.ORCID 0000-0002-8071-9394
Milaine Dominici SanfinsDepartment of Speech-Hearing-Language, Universidade Federal de São Paulo, São Paulo 04044-020, SP, Brazil.ORCID 0000-0002-3647-3999
Aline Buratti SanchesGraduate Program in Health, Interdisciplinarity and Rehabilitation, Faculty of Medical Sciences, State University of Campinas, Campinas 13083-887, SP, Brazil.
Gabriele Libano de Souza CardosoGraduate Program in Child and Adolescent Health, Faculty of Medical Sciences, State University of Campinas, Campinas 13083-887, SP, Brazil.
Ayla Gabrielle Paschoalon de MelloGraduate Program in Child and Adolescent Health, Faculty of Medical Sciences, State University of Campinas, Campinas 13083-887, SP, Brazil.
Piotr Henryk SkarzynskiDepartment of Teleaudiology and Screening, World Hearing Center, Institute of Physiology and Pathology of Hearing, 05-830 Warsaw, Poland.ORCID 0000-0002-4978-1915
Maria Francisca Colella-SantosFull Professor at Faculty of Medical Sciences, State University of Campinas, Campinas 13083-887, SP, Brazil.ORCID 0000-0002-7456-9502

Funding

National Council for Scientific and Technological Development 164767/2018-5
6 · The paper itself

Abstract

Central auditory processing efficiency is considered a predictor of how well children can learn to read, with the Frequency Following Response (FFR) serving as a sensitive biomarker of neural speech encoding ability. However, data regarding the 170 ms [da] stimulus in children who are native speakers of Brazilian Portuguese (BP) remain limited. This study investigated FFR results in 37 typically developing, normal-hearing children aged 8 to 10 years. Participants underwent audiological, behavioral, and academic performance screenings, followed by monaural FFR recording (using a 170 ms [da] stimulus at 80 dBnHL). Linear mixed models (LMM) were used to examine the effects of age, sex, and ear on the latencies of waves V, A, D, E, F, and O. The analysis revealed a medium effect size for waves D, E, and F, regarding the Ear factor, though statistical significance was specifically observed for wave E. For this wave, sex was also associated with a medium effect size, characterized by longer latencies in female participants. While the results for age did not reach broad statistical significance, the presence of medium effect sizes in wave E may suggest ongoing refinement of neural synchrony and asymmetric maturation during this developmental period. This study contributes to the characterization of neural speech encoding in the Brazilian Portuguese-speaking children and may support future investigation involving auditory processing disorders and learning difficulties.

Indexed as

frequency-following responseneural encodingschool-aged childrenspeech-evoked potentials

Identifiers

PMID42073502
PMCPMC13117995

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.