ArticleLife (Basel, Switzerland)2026
Asthma and Obstructive Sleep Apnea Overlap Syndrome Identifies a Phenotype of Sleep Instability and Increased Psychological Burden.
Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe alternative Overlap Syndrome (aOVS), the coexistence of bronchial asthma and Obstructive Sleep Apnea (OSA), represents a distinct clinical phenotype associated with worse clinical outcomes, but little is yet known about its characteristics. We aimed to investigate differences in sleep stability and clinical burden between OSA and aOVS patients matched for age, gender, BMI and Apnea-Hypopnea Index (AHI).
methods45 aOVS and 45 OSA patients were compared using demographic, clinical and polysomnographic data.
resultsPatients with aOVS exhibited significantly higher odds ratio product (ORP) values for total sleep time (ORPmed: 0.8 ± 0.2 vs. 0.5 ± 0.1,
conclusionsOur findings support the concept that aOVS is characterised by significantly more unstable sleep and a greater psychological burden, even after matching with OSA patients for age, gender, BMI and AHI. Our study also highlights the need to integrate traditional sleep measures with more recent ones, such as ORP, in order to better capture the multidimensional burden of aOVS.
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