ArticleLife (Basel, Switzerland)2026
Revisiting Colon Cancer Progression: A Containment-Based Conceptual Framework.
Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Patterns of colon cancer recurrence demonstrate a high degree of anatomical reproducibility, consistently aligning with mesofascial planes and compartmentalized vascular and lymphatic territories, as evidenced by pathological, surgical and imaging studies. These frameworks describe recognized routes of spread but do not provide an integrated anatomical explanation for understanding why tumor progression often aligns with mesofascial planes, embryological boundaries and cavity-specific niches, nor for why preservation of structural integrity during surgery is associated with improved oncological outcomes. This work proposes a spatial containment model of colon cancer progression, in which tumor dissemination reflects sequential breaches of anatomically defined barrier systems. The Colon Cancer Containment System is proposed as a three-tier framework in which tumor progression reflects sequential breaches of containment at the tissue (microcontainment), mesenteric (mesocontainment) and peritoneal or systemic (macrocontainment) levels. At each stage, anatomical structures function as barrier systems that constrain tumor spread and shape directionality of progression. Disruption of these barriers, whether tumor-driven or iatrogenic, is associated with relatively consistent patterns of local, regional, and distant recurrence. Within this approach, established prognostic features such as tumor-node-metastasis (TNM) stage, extramural vascular invasion, perineural invasion and margin status may also be interpreted as markers of containment integrity, in addition to their established roles as indicators of tumor aggressiveness. Surgical plane preservation is reframed as a biologically meaningful act of containment maintenance. By organizing validated observations within an anatomically patterned architecture, the containment framework provides a coherent model for interpreting reproducible recurrence patterns and clarifies the biological significance of surgical integrity. This perspective complements existing oncological paradigms, supports anatomically informed risk stratification and generates testable hypotheses for future clinical and translational research.
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