Evidence map›Paper›PMID 42073302›Full record

ArticleFoods (Basel, Switzerland)2026

ACE-Inhibitory Peptides from Yanbian Cattle Hemoglobin: Screening, Kinetics, and Molecular Dynamics Simulation.

Shihan Yang, Tingting Gao, Bowen Qin, Chenguang Li, Chunxiang Piao, Mingxun Cui, Hongmei Li, Baide Mu, Juan Wang, Tingyu Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shihan YangCollege of Agriculture, Yanbian University, Yanji 133000, China.
Tingting GaoCollege of Agriculture, Yanbian University, Yanji 133000, China.
Bowen QinCollege of Agriculture, Yanbian University, Yanji 133000, China.
Chenguang LiCollege of Agriculture, Yanbian University, Yanji 133000, China.
Chunxiang PiaoCollege of Agriculture, Yanbian University, Yanji 133000, China.
Mingxun CuiCollege of Agriculture, Yanbian University, Yanji 133000, China.
Hongmei LiCollege of Agriculture, Yanbian University, Yanji 133000, China.
Baide MuCollege of Agriculture, Yanbian University, Yanji 133000, China.
Juan WangCollege of Agriculture, Yanbian University, Yanji 133000, China.
Tingyu LiCollege of Agriculture, Yanbian University, Yanji 133000, China.
Qingwei JiangKey Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China.
Aihui LvKey Innovation Laboratory for Deep and Intensive Processing of Yanbian High Quality Beef, Ministry of Agriculture and Rural Affairs, Yanbian University, Yanji 133000, China.
Guanhao LiCollege of Agriculture, Yanbian University, Yanji 133000, China.

Funding

the Department of Science and Technology of Jilin province 20240303050NCthe Department of Science and Technology of Jilin province 20250202064NC
6 · The paper itself

Abstract

The global burden of hypertension continues to rise, highlighting an urgent need for effective therapeutic strategies. Angiotensin-converting enzyme (ACE) is central to blood pressure regulation, but commonly used synthetic ACE inhibitors often have adverse side effects, spurring the search for safer natural alternatives. The aim of this study was to investigate Yanbian cattle hemoglobin as a novel precursor for ACE inhibitory peptides. The <1 kDa fraction was identified as exhibiting the highest inhibitory activity through the systematic screening of hydrolysates across multiple molecular weight ranges. LC-MS/MS analysis identified 1980 peptides, of which four were selected for further experiments. Solid-phase synthesis confirmed that NFGYDL exhibited the strongest ACE inhibition (IC

Indexed as

ACE inhibitory peptidesbovine bloodmolecular dockingmolecular dynamics simulationYanbian yellow cattle

Identifiers

PMID42073302
PMCPMC13115288

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.