Geographical Discrimination of Xinhui Citri Reticulatae Pericarpium by DART-QTOF-MS.

Ximei Wu, Qunjie Feng, Wenbo Duan, Wei Tong, Jian Wen, Gangqiang Ding

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Ximei WuNHC Specialty Laboratory of Food Safety Risk Assessment and Standard Development, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.

Qunjie FengNHC Specialty Laboratory of Food Safety Risk Assessment and Standard Development, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.

Wenbo DuanCarbon Neutrality and Climate Change Thrust, Society Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511453, China.

Wei TongNHC Specialty Laboratory of Food Safety Risk Assessment and Standard Development, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.

Jian WenNHC Specialty Laboratory of Food Safety Risk Assessment and Standard Development, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.

Gangqiang DingNHC Specialty Laboratory of Food Safety Risk Assessment and Standard Development, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.

Funding

the Guangdong Provincial Medical Research Fund 20241120143036566

6 · The paper itself

Abstract

Xinhui Citri Reticulatae Pericarpium (CRP, "Chenpi") is highly valued but is frequently challenged by origin-related adulteration and mislabeling. In this study, a rapid fingerprinting strategy based on direct analysis in real-time quadrupole time-of-flight mass spectrometry (DART-QTOF-MS) coupled with chemometric analysis was developed for the geographical characterization of CRP. DART-QTOF-MS enabled fast acquisition of mass spectral fingerprints with minimal sample preparation, and characteristic compounds were tentatively assigned on the basis of accurate mass and library matching. Comparative analysis showed that the high-mass region was dominated by polymethoxylated flavones and exhibited relatively limited between-region variation. In contrast, the low-mass region contained more evident origin-related differences and provided more informative variables for classification. Among the low-molecular-weight compounds, methyl N-methylanthranilate was markedly enriched in Xinhui samples, and 2-indolinone was identified as a promising candidate marker and further confirmed in CRP extracts by UPLC-MS/MS. OPLS-DA based on selected low-molecular-weight markers supported the discrimination of core Xinhui CRP and non-core Xinhui CRP. Overall, these results demonstrate the potential of DART-QTOF-MS as a screening tool for CRP origin authentication and highlight the value of low-molecular-weight markers for future quality-control applications.

Indexed as

2-indolinoneCitri Reticulatae PericarpiumDART-QTOF-MSgeographical origin discriminationrapid fingerprinting

Identifiers

PMID42073250

DOI10.3390/foods15081361

PMCPMC13115399

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.