Integrated Metabolomics and Network Pharmacology Reveal the Active Components and Potential Health-Beneficial Mechanisms of Different Jujube (

Yuanru Chen, Xueling Zeng, Wei Qin, Wenjuan Geng, Ruocheng Tang, Ximo Bai, Weiquan Zhou

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Yuanru ChenCollege of Horticulture, Xinjiang Agricultural University/Xinjiang Institute of Jujube Industrial Development/Xinjiang Engineering Research Center for Efficient Cultivation and High-Value Utilization of Forest and Fruit Crops, Urumqi 830000, China.ORCID 0009-0005-6896-541X

Xueling ZengCollege of Horticulture, Xinjiang Agricultural University/Xinjiang Institute of Jujube Industrial Development/Xinjiang Engineering Research Center for Efficient Cultivation and High-Value Utilization of Forest and Fruit Crops, Urumqi 830000, China.

Wei QinCollege of Horticulture, Xinjiang Agricultural University/Xinjiang Institute of Jujube Industrial Development/Xinjiang Engineering Research Center for Efficient Cultivation and High-Value Utilization of Forest and Fruit Crops, Urumqi 830000, China.

Wenjuan GengCollege of Horticulture, Xinjiang Agricultural University/Xinjiang Institute of Jujube Industrial Development/Xinjiang Engineering Research Center for Efficient Cultivation and High-Value Utilization of Forest and Fruit Crops, Urumqi 830000, China.

Ruocheng TangCollege of Horticulture, Xinjiang Agricultural University/Xinjiang Institute of Jujube Industrial Development/Xinjiang Engineering Research Center for Efficient Cultivation and High-Value Utilization of Forest and Fruit Crops, Urumqi 830000, China.

Ximo BaiCollege of Horticulture, Xinjiang Agricultural University/Xinjiang Institute of Jujube Industrial Development/Xinjiang Engineering Research Center for Efficient Cultivation and High-Value Utilization of Forest and Fruit Crops, Urumqi 830000, China.

Weiquan ZhouCollege of Horticulture, Xinjiang Agricultural University/Xinjiang Institute of Jujube Industrial Development/Xinjiang Engineering Research Center for Efficient Cultivation and High-Value Utilization of Forest and Fruit Crops, Urumqi 830000, China.ORCID 0000-0001-6100-5487

Funding

Graduate Research Innovation Project of Xinjiang Agricultural University XJAUGRI2025070Major Science and Technology Project of Xinjiang Uygur Autonomous Region 2023A02010-1Xinjiang Uygur Autonomous Region "Tianshan Talents" Cultivation Program "Three Rural" Bone Thousand Talents - High-level Talents for Modern Agriculture and Animal Husbandry Development 2023SNGGGCC012

6 · The paper itself

Abstract

The health benefits of jujubes are closely related to their active substances. In this study, the active substances in 'huizao' (HZ), 'junzao' (JZ), 'hamidazao' (HMDZ), 'kashigerexiaozao' (KSGEXZ) and 'yuanlingzao' (YLZ) jujube varieties were identified via ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). After identification, a total of 1583 metabolites were found in jujube fruits, covering 13 major categories including alkaloids, amino acids and their derivatives. Pairwise comparisons revealed 518-755 differentially abundant metabolites across cultivars, and each variety had its main dominant metabolites. Through network pharmacology, 141 potential disease-related bioactive compounds were screened out, and key compounds were identified through molecular docking. These substances bind to the key target TP53 through hydrogen bonding and hydrophobic interactions. Among them, catechin, naringenin, and coniferin had the strongest binding affinities. These data increase our understanding of the active components of jujube and provide valuable information for the sustainable cultivation of jujubes for health applications.

Indexed as

Chinese jujube fruitmetabolitemolecular dockingpharmacological componentswidely targeted metabolomics

Identifiers

PMID42073234

DOI10.3390/foods15081347

PMCPMC13115148

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.