ReviewChildren (Basel, Switzerland)2026
Neuromorphological Alterations in the Somatosensory System of Adolescent Idiopathic Scoliosis: A Systematic Review of Magnetic Resonance Imaging Studies.
Review in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Presynaptic Terminal Alterations in Concave and Convex Spinalis Muscles: A Pilot Exploratory Study in Advanced Scoliosis.Journal of clinical medicine · 2026Article
- Retained primitive reflexes are independently associated with impaired postural control in adolescents with idiopathic scoliosis.Frontiers in neurology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
BACKGROUND/
objectivesThis systematic review synthesizes MRI evidence to characterize neuromorphological alterations in somatosensory and vestibular brain regions among adolescents with idiopathic scoliosis (AIS).
methodsThis systematic review was conducted in accordance with the PRISMA 2020 guidelines. We systematically searched five databases from inception to January 2026 for case-control MRI studies comparing AIS patients (10-18 years) with healthy controls. Two reviewers independently screened studies, extracted data, and assessed the risk of bias using the Newcastle-Ottawa Scale.
resultsAcross 15 studies (1270 participants), AIS patients demonstrated consistent neuromorphological alterations: (1) lower cerebellar tonsil position (0.9-2.8 mm below baseline), with ectopia incidence correlating with curve severity; (2) cortical thickening in bilateral medial regions but thinning in left paracentral areas; (3) left-dominant white matter volume increases and impaired microstructure in the corpus callosum; and (4) left-sided vestibular morphological changes, including a more vertical semicircular canal.
conclusionsAIS is associated with consistent neuromorphological alterations in key somatosensory and vestibular regions, supporting a potential neuroanatomical basis for impaired sensorimotor integration in its pathogenesis. It should be noted that substantial heterogeneity among the included studies prevented a meta-analysis, and the cross-sectional design limits causal interpretations Registration: This systematic review was registered in PROSPERO (CRD42024577195).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.