Evidence map›Paper›PMID 42072711›Full record

ArticleBiomolecules2026

Ezetimibe Normalizes Dietary Cholesterol-Induced Exacerbation of Liver Injury in Alcohol-Fed Mice.

Yanchao Xu, Nan Zhang, Piumi B Wickramasinghe, Kavya Veera, Preethi Parupalli, Alex Dao, Junyu Liu, Rithika Anand, Lyndsey E Langley, Sreeja Eadha and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yanchao XuDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Nan ZhangDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Piumi B WickramasingheDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Kavya VeeraDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Preethi ParupalliDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Alex DaoDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Junyu LiuDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Rithika AnandDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Lyndsey E LangleyDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Sreeja EadhaDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Hasan IqbalDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Chen LiuCenter for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Fang BianDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0000-0002-1995-4416
Lin JiaDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0000-0002-7653-7395

Funding

Hypothalamic Serotonin Receptors and Olanzapine-induced Metabolic SyndromeR01DK114036 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Chen Liu · 2017 to 2026
$4.2M
Transcriptional Control of Melanocortin 4 Receptors and Obesity RiskR01DK130892 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Chen Liu · 2022 to 2026
$2.4M
Deconstruct Raphe Serotonin Neurons that Regulate SatietyR01DK136592 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Chen Liu · 2024 to 2026
$1.5M
National Institute of Health AA028585NIDDK NIH HHS R01 DK114036NIDDK NIH HHS R01 DK130892NIDDK NIH HHS R01 DK136592The University of Texas at Dallas New Faculty Research Symposium Grant
6 · The paper itself

Abstract

Interactions between alcohol and nutrition play an important role in the development and progression of alcohol-associated liver disease (ALD). Although dietary cholesterol was shown to exacerbate fatty liver and liver injury in alcohol-fed mice, findings regarding the combined effect of dietary cholesterol and heavy alcohol drinking on cholesterol homeostasis remain controversial. Ezetimibe has been widely used as a cholesterol-lowering drug in hypercholesterolemic subjects. It is not fully understood whether ezetimibe blunts the adverse effect of cholesterol on lipid and biliary bile acid metabolism in alcohol-exposed mice. In the current study, wild-type mice were subjected to NIAAA alcohol feeding model. Dietary cholesterol (0.2%,

Indexed as

Anticholesteremic AgentsCholesterol, DietaryEthanolEzetimibeLiver Diseases, AlcoholicAnimalsBile Acids and SaltsCholesterolLiverMaleMiceMice, Inbred C57BLTriglyceridesAnticholesteremic AgentsBile Acids and SaltsCholesterolCholesterol, DietaryEthanolEzetimibeTriglyceridesALDbiliary bile acidcholesterol biosynthesisdietary cholesterolezetimibefatty liver

Identifiers

PMID42072711
PMCPMC13113872

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.