Evidence map›Paper›PMID 42072669›Full record

ArticleBiomolecules2026

CTCF Regulates Erythroid Differentiation Through Control of Core Erythroid Transcription Factors.

Lorena García-Gaipo, Vanessa Junco, Lucía García-Gutiérrez, Verónica Torrano, Rosa Blanco, Alexandra Wiesinger, Rujula Pradeep, Jose Luis Arroyo, Ana Batlle-López, Javier León and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lorena García-GaipoInstitute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC-University of Cantabria, 39011 Santander, Spain.ORCID 0000-0002-5998-0344
Vanessa JuncoInstitute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC-University of Cantabria, 39011 Santander, Spain.ORCID 0000-0001-5782-6370
Lucía García-GutiérrezInstitute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC-University of Cantabria, 39011 Santander, Spain.ORCID 0000-0003-4396-4814
Verónica TorranoDepartment of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.
Rosa BlancoInstitute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC-University of Cantabria, 39011 Santander, Spain.
Alexandra WiesingerInstitute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC-University of Cantabria, 39011 Santander, Spain.
Rujula PradeepDepartment of Data Science, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA.ORCID 0009-0000-2175-6024
Jose Luis ArroyoBlood and Tissue Bank of Cantabria, Marqués de Valdecilla Foundation, Marqués de Valdecilla Research Institute (IDIVAL), 39011 Santander, Spain.
Ana Batlle-LópezInstitute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC-University of Cantabria, 39011 Santander, Spain.
Javier LeónInstitute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC-University of Cantabria, 39011 Santander, Spain.ORCID 0000-0001-5803-0112
Manuel Rosa-GarridoInstitute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC-University of Cantabria, 39011 Santander, Spain.ORCID 0000-0002-2169-3972
M Dolores DelgadoInstitute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC-University of Cantabria, 39011 Santander, Spain.ORCID 0000-0003-4682-4040

Funding

MCIN/ AEI/10.13039/501100011033/, Spanish Government, and "FEDER, Una manera de hacer Europa", European Union SAF2017-88026-R and PID2020-115903GB-100
6 · The paper itself

Abstract

Erythropoiesis is tightly regulated by lineage-specific transcription factors that govern erythroid commitment, proliferation, and differentiation. A core erythroid transcriptional network, together with non-DNA-binding cofactors, occupies regulatory regions of genes essential for erythroid development. This process is further shaped by epigenetic mechanisms, including histone post-translational modifications and long-range chromatin interactions. CCCTC-binding factor (CTCF) is a multifunctional regulator with a central role in three-dimensional chromatin organization. Although CTCF has been implicated in hematopoietic differentiation and leukemogenesis, its specific function in erythropoiesis remains poorly defined. Here, we investigated the role of CTCF during erythroid differentiation using two complementary models: pluripotent K562 leukemia cells and primary human CD34

Indexed as

CCCTC-Binding FactorCell DifferentiationErythroid CellsErythropoiesisTranscription FactorsCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinsHematopoietic Stem CellsHumansK562 CellsKruppel-Like Transcription FactorsCCCTC-Binding FactorCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinsCTCF protein, humanerythroid Kruppel-like factorKruppel-Like Transcription FactorsTranscription FactorsCTCFerythroid transcription factorserythropoiesisETS1KLF1LMO2MYB

Identifiers

PMID42072669
PMCPMC13113740

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.