Evidence map›Paper›PMID 42072668›Full record

ArticleBiomolecules2026

Behavior and Musculoskeletal Effects of Chronic D-Galactose Treatment in Mice: Role of Heme Oxygenase-1.

Sally Wahba, Olufunto O Badmus, Andrew R Wasson, Elshymaa A Abdel-Hakeem, Merhan Mamdouh Ragy, Hanaa Mohamad Ibrahim, Daniela Rüedi-Bettschen, David E Stec

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sally WahbaDepartment of Physiology & Biophysics, Cardiovascular-Renal Research Center, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0009-0005-3514-5992
Olufunto O BadmusDepartment of Physiology & Biophysics, Cardiovascular-Renal Research Center, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0002-1020-2170
Andrew R WassonDepartment of Physiology & Biophysics, Cardiovascular-Renal Research Center, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Elshymaa A Abdel-HakeemDepartment of Medical Physiology, Faculty of Medicine, Minia University, Minya 61519, Egypt.ORCID 0000-0001-6303-9752
Merhan Mamdouh RagyDepartment of Medical Physiology, Faculty of Medicine, Minia University, Minya 61519, Egypt.
Hanaa Mohamad IbrahimDepartment of Medical Physiology, Faculty of Medicine, Minia University, Minya 61519, Egypt.
Daniela Rüedi-BettschenDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0003-2393-6824
David E StecDepartment of Physiology & Biophysics, Cardiovascular-Renal Research Center, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0001-8359-4008

Funding

Pilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI John E Hall · 2023 to 2026
$6.3M
Fullbright Fulbright Foreign Student ProgramNational Heart Lung and Blood Institute 1R01HL174521-01A1NIGMS NIH HHS P30GM149404
6 · The paper itself

Abstract

Chronic d-galactose (d-gal) treatment is a model to induce accelerated aging-like phenotypes in rodents. However, the sex differences in behavioral and musculoskeletal manifestations of this model are not well understood. Heme oxygenase-1 (HO-1) is a cytoprotective protein that may have anti-aging properties. The goal of this study was to better understand the sex differences in the behavioral and musculoskeletal effects of chronic d-gal treatment in C57BL/6J mice, as well as the role of HO-1 induction or inhibition. Eight-week-old male and female mice received daily saline or d-gal injections (500 mg/kg, s.c.) for 12 weeks. After this time, mice in the d-gal group were randomized into three groups (

Indexed as

Behavior, AnimalGalactoseHeme Oxygenase-1AgingAnimalsFemaleMaleMiceMice, Inbred C57BLProtoporphyrinsSex CharacteristicsGalactoseHeme Oxygenase-1Protoporphyrinsagingbrainmemoryoxidative stress

Identifiers

PMID42072668
PMCPMC13113933

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.