Evidence map›Paper›PMID 42072663›Full record

ArticleBiomolecules2026

A Cisplatin-Based Prodrug Inhibits Nucleotide Excision Repair Independently of Chromatin Accessibility to Overcome Resistance.

Ya'ara Negev-Korem, Hadar Golan-Berman, Elisheva Heilbrun, Subhendu Karmakar, Yoram Soroka, Marina Frušić-Zlotkin, Ofer Chen, Hiba Hassanain, Esther Stern, Ori Wald and 3 more

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ya'ara Negev-KoremDepartment of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.ORCID 0009-0009-3911-1043
Hadar Golan-BermanDepartment of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.ORCID 0000-0002-3372-9717
Elisheva HeilbrunDepartment of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Subhendu KarmakarInstitute for Drug Research, School of Pharmacy, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.ORCID 0000-0002-4840-3015
Yoram SorokaThe Myers Skin Research Laboratory, Institute for Drug Research, School of Pharmacy, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9103401, Israel.
Marina Frušić-ZlotkinThe Myers Skin Research Laboratory, Institute for Drug Research, School of Pharmacy, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9103401, Israel.ORCID 0000-0001-7142-3359
Ofer ChenDepartment of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.ORCID 0009-0009-5603-983X
Hiba HassanainDepartment of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Esther SternGene Therapy Institute, Hadassah Medical Center, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Ori WaldGene Therapy Institute, Hadassah Medical Center, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Dan GibsonInstitute for Drug Research, School of Pharmacy, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.ORCID 0000-0002-1631-4018
Ron KohenThe Myers Skin Research Laboratory, Institute for Drug Research, School of Pharmacy, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9103401, Israel.ORCID 0000-0001-7268-9845
Sheera AdarDepartment of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.ORCID 0000-0002-9767-3740

Funding

Israel Cancer Association 20191630, 20210078Israel Science Foundation 1710/17, 482/22, 1002/18, 1728/20the Alex Grass Center for Drug Design and Novel Therapeutics 3175006046
6 · The paper itself

Abstract

Cisplatin [

Indexed as

Antineoplastic AgentsChromatinCisplatinDrug Resistance, NeoplasmExcision RepairProdrugsCell Line, TumorDNA DamageDNA RepairHumansAntineoplastic AgentsChromatinCisplatinProdrugschromatincisplatinDNA damageDNA repairKDACNrf2nucleotide excision repairPt(IV)

Identifiers

PMID42072663
PMCPMC13113776

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.