Evidence map›Paper›PMID 42072652›Full record

ArticleBiomolecules2026

NANOG Proximity Proteomics Maps Neighborhood Hubs Linked to Mesenchymal Stem Cell Stemness and Chromatin Control.

Kyoung-Jae Choi, Michail Tyryshkin, Harathi Jonnagaddala, Allan Chris M Ferreon, Marian Kalocsay, Josephine C Ferreon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kyoung-Jae ChoiDepartment of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9541-4182
Michail TyryshkinDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Harathi JonnagaddalaDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0001-6014-8603
Allan Chris M FerreonDepartment of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-8538-1732
Marian KalocsayDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-4187-5829
Josephine C FerreonDepartment of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-3175-5700

Funding

Structure and Functionof Nanog in Stem Cell PluripotencyR01GM122763 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI Josephine Chu Ferreon · 2018 to 2026
$3.4M
Phase Transition-Mediated Tau Function and DysfunctionR01NS105874 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI FERREON, ALLAN CHRIS · 2019 to 2023
$2.0M
Cancer Prevention and Research Institute of Texas RR220032NIGMS NIH HHS R01 GM122763NINDS NIH HHS R01 NS105874
6 · The paper itself

Abstract

NANOG overexpression has been reported to reverse aging-associated decline in mesenchymal stem/stromal cell (MSC) function, but the molecular machinery engaged by NANOG in MSCs remains incompletely defined. Here, we applied APEX proximity labeling coupled with quantitative mass spectrometry to define the NANOG proximity interactome (proxeome) in human MSCs. Of 1040 quantified proteins, 828 were significantly enriched in the APEX-NANOG (H

Indexed as

ChromatinMesenchymal Stem CellsNanog Homeobox ProteinProteomicsHumansChromatinNanog Homeobox ProteinNANOG protein, humanagingAPEXchromatin remodelingDNA replicationmechanotransductionmesenchymal stem/stromal cellsNANOGproximity proteomicsrejuvenationRNA processingtranscription elongation

Identifiers

PMID42072652
PMCPMC13113505

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.