ReviewBiomolecules2026
The Complement System in the Setting of Critical Illness-A Narrative Review.
Review in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Rare bacterial infections and metagenomics: current diagnostic and therapeutic challenges-a literature review.Infection · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complement system is a key component of innate immunity, known primarily as an immune surveillance mechanism. However, it is also widely known as a modulator of immune responses and inflammation, and its activation has been reported in a wide array of conditions that can lead to admission to the intensive care unit (ICU). Furthermore, various ICU monitoring practices and treatment interventions of the ICU needed to sustain vital organ function may disrupt complement homeostasis. In this review, we will describe in detail the role of the complement system in various critical care settings, with emphasis on major ICU-related conditions such as bacterial and viral sepsis, trauma and burn. Additionally, we will address the potential value of this complex cascade as a prognosis tool and the possible implications for clinical practice as well as its potential as a target for future innovative therapeutic strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.