ArticleBiomolecules2026
Differential Contributions of IgM and IgG Autoantibodies to Serologic IA2 Reactivity in Type 1 Diabetes.
Xuming Mao, Jake Konigsberg, Nadia Noorchashm, Wenzhao Meng, James J Knox, Gregory J Golden, Jacob T Hamilton, Tara K Maxwell, Chengyang Liu, Michael R Betts and 4 more
Abstract read
In one paragraphArticle in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
14 authors.
Xuming MaoDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-4232-8103 Jake KonigsbergDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0009-0008-0473-0437 Nadia NoorchashmDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wenzhao MengDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
James J KnoxDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gregory J GoldenBreakthrough T1D, New York, NY 10281, USA.
Jacob T HamiltonInstitute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-1277-6925 Tara K MaxwellDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0001-8751-8598 Chengyang LiuDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael R BettsInstitute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Steven M WilliDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-4910-2425 Ali NajiInstitute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Eline T Luning PrakDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-9478-9211 Funding
Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes PWD&RPP-MRI; Project No. JYY2023-14Breakthrough T1D PNF-2016-337-S-BNational Natural Science Foundation of China Grant No. 82273130 to T.M.NIAID NIH HHS U19-AI110483NIDDK NIH HHS U01-DK112217
6 · The paper itselfAbstract
Autoantibodies targeting islet antigen 2 (IA2) are critical diagnostic and prognostic markers for type 1 diabetes (T1D). Standard clinical assays do not differentiate between IgG and IgM isotypes, yet these antibodies have distinct roles in the T1D autoimmunity. We therefore adapted electrochemiluminescence (ECL) assays to separately detect IgG and IgM antibodies against the IA2 intracellular domain (AA601-979). Assay specificity was confirmed by indirect immunofluorescence, which showed autoantibody binding to IA2-overexpressing cells. Plasma samples were analyzed from two independent cohorts: organ donors of the Human Pancreas Analysis Program (HPAP,
Indexed as
AutoantibodiesDiabetes Mellitus, Type 1Immunoglobulin GImmunoglobulin MReceptor-Like Protein Tyrosine Phosphatases, Class 8AdolescentAdultChildChild, PreschoolFemaleHumansMaleAutoantibodiesImmunoglobulin GImmunoglobulin MReceptor-Like Protein Tyrosine Phosphatases, Class 8autoantibodieselectrochemiluminescence (ECL)Immunoglobulin G (IgG)Immunoglobulin M (IgM)islet antigen 2 (IA2)type 1 diabetes (T1D)
Identifiers
PMID42072622
PMCPMC13113336
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