ATG5-FOXA3 Axis Contributes to Lysosomal Biogenesis and Auditory Function in Kölliker's Organ.

Penghui Chen, Jifang Zhang, Ying Wang, Jiarui Chen

Abstract read

In one paragraph

Article in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Penghui ChenDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Children's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.

Jifang ZhangDepartment of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200082, China.ORCID 0000-0001-9258-1591

Ying WangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Children's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.

Jiarui ChenDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Children's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.

Funding

National Science Foundation of China 82000989Shanghai Sailing Program 20YF1428800

6 · The paper itself

Abstract

backgroundKölliker's organ (KO) support cells undergo orderly, time-dependent degeneration that is essential for auditory development and is accompanied by precisely regulated autophagic activity; however, the molecular hierarchy linking autophagy to this remodeling remains obscure. This study aimed to elucidate the regulatory mechanisms connecting autophagic flux to lysosomal biogenesis and auditory function during cochlear development.

methodWe established an

resultsAt 2 months of age,

conclusionsThese findings support a model wherein the ATG5-FOXA3 axis contributes to lysosomal biogenesis in developing KO cells, with implications for understanding mechanisms of congenital sensorineural hearing loss.

Indexed as

ATG5auditory developmentFOXA3Kölliker’s organlysosome

Identifiers

PMID42072344

DOI10.3390/biomedicines14040802

PMCPMC13113778

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.