Effects of Purkinje Fiber Conduction Block on Cardiac Pump Function: Computational Modeling Study.

Sandra P Hager, Vahid Ziaei-Rad, Jenny S Choy, Mengjun Wang, Ghassan S Kassab, Lik Chuan Lee

Abstract read

In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sandra P HagerDepartment of Mechanical Engineering, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-0681-596X

Vahid Ziaei-RadDepartment of Mechanical Engineering, Michigan State University, East Lansing, MI 48824, USA.

Jenny S ChoyCalifornia Medical Innovations Institute, San Diego, CA 92121, USA.ORCID 0000-0002-7032-0777

Mengjun WangCalifornia Medical Innovations Institute, San Diego, CA 92121, USA.

Ghassan S KassabCalifornia Medical Innovations Institute, San Diego, CA 92121, USA.

Lik Chuan LeeDepartment of Mechanical Engineering, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-1123-6428

Funding

Mathematical Model-Based Optimization of CRT Response in IschemiaR01HL166508 · NHLBI · CALIFORNIA MEDICAL INNOVATIONS INSTITUTE · PI GHASSAN S KASSAB, Lik Chuan Lee · 2023 to 2026

$3.1M

Foundation for the National Institutes of Health R01HL166508NHLBI NIH HHS R01 HL166508Office of Small Business Innovation Research and Small Business Technology Transfer Programs R43HL174177

6 · The paper itself

Abstract

Cardiac and hemodynamic conditions such as myocardial infarct, cardiomyopathy, hypertension, and aortic valve disease can impair conduction within the Purkinje fiber network and compromise left ventricular (LV) pump function. We developed a computational framework that couples electrical propagation in a structurally organized Purkinje fiber network with LV electromechanics to analyze the impact of conduction abnormalities on cardiac performance. A

Indexed as

cardiac modelingelectromechanics couplingelectrophysiologyexcitation–contraction couplingfinite element methodleft bundle branch blockPurkinje fiber network

Identifiers

PMID42072258

DOI10.3390/bioengineering13040464

PMCPMC13113160

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.