The Cortical Contributions to Turning Performance Through Muscle Synergies in Parkinson's Disease: A Mediation Study.

Mirabel Ewura Esi Acquah, Zengguang Wang, Wei Chen, Dongyun Gu

Abstract read

In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mirabel Ewura Esi AcquahSchool of Biomedical Engineering, Shanghai Jiao Tong University, No. 1954 Huashan Road, Xuhui District, Shanghai 200030, China.

Zengguang WangSchool of Biomedical Engineering, Shanghai Jiao Tong University, No. 1954 Huashan Road, Xuhui District, Shanghai 200030, China.

Wei ChenDepartment of Neurology, Shanghai Ninth People's Hospital, No. 833 Zhizaoju Road, Huangpu District, Shanghai 200011, China.

Dongyun GuSchool of Biomedical Engineering, Shanghai Jiao Tong University, No. 1954 Huashan Road, Xuhui District, Shanghai 200030, China.

Funding

National Key Research and Development Program of China 2022YFC2009502National Natural Science Foundation of China 11972233

6 · The paper itself

Abstract

Turning impairment is a major contributor to falls in Parkinson's disease (PD), yet the mechanisms linking cortical dysfunction to altered motor behavior remain unclear. In particular, it is unknown whether disrupted cortical communication impairs turning by altering muscle coordination. This study investigates a novel mechanistic pathway: whether muscle synergy complexity mediates the relationship between cortical network connectivity and turning performance in PD. Specifically, electroencephalography (EEG) and electromyography (EMG) were recorded from 12 individuals with PD and 12 age-matched healthy controls during a 180° turning task. Directed cortical connectivity, muscle synergy complexity, and spatiotemporal turning performance were quantified. Mediation analysis was used to determine whether cortical influences on behavior operate indirectly through neuromuscular coordination. Compared to controls, individuals with PD performed slower turns with shorter stride lengths and reduced synergy complexity (

Indexed as

functional connectivitymediation analysismotor controlmuscle synergyParkinson’s diseaseturning

Identifiers

PMID42072247

DOI10.3390/bioengineering13040453

PMCPMC13113805

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.