Integrating Distance Correlation and Adaptive Weighting with RBF Kernel Transformations: A Novel Feature Selection Framework with Application to ECG Arrhythmia Detection.

Accurate feature selection is critical for machine learning in medical diagnosis, yet conventional methods often fail to capture complex non-linear relationships in biomedical data. This study introduces an advanced feature selection approach that integrates distance correlation with adaptive weighting to enhance cardiac arrhythmia detection. The proposed method ranks features based on distance correlation, applies an inverse penalty weighting scheme to suppress highly correlated features while emphasizing moderately correlated ones, and incorporates RBF kernel transformation followed by LASSO refinement. Fifteen feature selection techniques were evaluated on an electrocardiographic database of 279 morphological and physiological features using 4-fold cross-validation with a neural network classifier. The proposed method outperformed all alternatives, including the best conventional approach, by effectively capturing non-linear dependencies, mitigating multicollinearity and overfitting, and leveraging synergistic kernel-based interaction modeling with sparse selection. These results demonstrate that combining statistical dependence measures, adaptive regularization, and non-linear transformations provides a robust framework for feature selection in cardiac arrhythmia classification and broader medical informatics applications.