An Optimal Deep Hybrid Framework with Selective Kernel U-Net for Skin Lesion Detection and Classification.

Early and accurate detection of skin cancer is critical for reducing mortality rates, particularly for malignant melanoma. Automated analysis of dermoscopic images has gained significant attention due to its potential to support clinical diagnosis and overcome the limitations of manual inspection. Motivated by challenges such as image noise, low contrast, lesion variability, and redundant feature representation, this study proposes an optimal deep hybrid framework for skin lesion detection and classification. The objective of this work is to design a robust and efficient system that integrates advanced preprocessing, precise segmentation, optimal feature selection, and accurate classification. Initially, contrast enhancement using Contrast Limited Adaptive Histogram Equalization (CLAHE) and noise reduction using Wiener filtering are applied to improve image quality. Lesion regions are then segmented using a Selective Kernel U-Net (SK-UNet), which adaptively captures multi-scale spatial information. Subsequently, discriminative color, texture, and shape features are extracted and optimized using the Fossa Optimization Algorithm (FOA) to eliminate redundancy. A hybrid one-dimensional Convolutional Neural Network-Gated Recurrent Unit (1D-CNN-GRU) classifier is employed for final classification, learning both spatial and sequential feature patterns. Experimental evaluation on the ISIC and DermMNIST datasets demonstrates that the proposed framework achieves classification accuracies of 97.6% and 95.6%, respectively, outperforming several existing methods. The results confirm that the proposed hybrid framework provides reliable, accurate, and scalable skin cancer diagnosis, highlighting its potential for assisting clinical decision-making and early detection.