Personalized Simulation Modeling of Overlapping Microwave Ablation for Large Tumors.

This paper evaluates the advantages of overlapping microwave ablation (OMWA) for the personalized treatment of large tumors, providing quantitative and technical references for conformal tumor eradication. A three-dimensional numerical model coupled with electromagnetic fields and Pennes' biological heat transfer equation was constructed, comprehensively considering the nonlinear behavior of tissue electrical and thermal parameters with temperature changes. A simulation model was developed to predict temperature distribution and the formation of the coagulation zone under single-needle multiple-point and multiple-needle multiple-point OMWA strategies. The LiTS2017 public dataset of liver tumor cases and real clinical cases was selected for verification. The results showed that OMWA could achieve faster thermal accumulation, higher central temperature, and more conformal tumor coverage. Compared with the single-needle strategy, OMWA significantly reduces thermal damage to surrounding healthy tissues while achieving complete tumor coverage. Therefore, OMWA is more efficient and safer than the single-needle strategy in the personalized treatment of large tumors and can provide important references for clinical preoperative planning and parameter optimization.