Evidence map›Paper›PMID 42072107›Full record

ArticleAntioxidants (Basel, Switzerland)2026

The c-Abl-RIPK3 Axis Drives Mitochondrial Dysfunction and Impaired Mitophagy in Gaucher Disease Models.

Cristian M Lamaizon, Renatta Tironi-Hernández, Nohela B Arévalo, Sebastián D Ahumada, Daniela A Gutiérrez, Laura Brito-Fernández, Andrea Del Campo, Silvana Zanlungo, Alejandra R Álvarez

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cristian M LamaizonCell Signaling Laboratory, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.ORCID 0000-0001-8515-3804
Renatta Tironi-HernándezCell Signaling Laboratory, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.
Nohela B ArévaloCell Signaling Laboratory, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.
Sebastián D AhumadaCell Signaling Laboratory, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.
Daniela A GutiérrezCell Signaling Laboratory, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.ORCID 0000-0001-5823-8044
Laura Brito-FernándezDepartment of Gastroenterology, Medicine Faculty, Pontificia Universidad Católica de Chile, Santiago 8320165, Chile.
Andrea Del CampoPhysiology and Cell Bioenergetics Laboratory, Pharmacy School, Chemistry and Pharmacy Faculty, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile.
Silvana ZanlungoDepartment of Gastroenterology, Medicine Faculty, Pontificia Universidad Católica de Chile, Santiago 8320165, Chile.ORCID 0000-0001-8383-9829
Alejandra R ÁlvarezCell Signaling Laboratory, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.

Funding

Agencia Nacional de Investigación y Desarrollo 202045Fondo Nacional de Desarrollo Científico y Tecnológico 1230337Fondo Nacional de Desarrollo Científico y Tecnológico 1230428Fondo Nacional de Desarrollo Científico y Tecnológico 1241503Fundación Nacional para el Desarrollo 25I10566
6 · The paper itself

Abstract

Gaucher disease (GD) is characterized by the accumulation of glucosylceramide within lysosomes due to mutations in the

Indexed as

autophagyc-AblGaucher diseaselysosomal storage disordersmitochondrial dysfunctionmitophagyoxidative stressRIPK3

Identifiers

PMID42072107
PMCPMC13113124

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.