Targeting Inhibin Enhances Wagyu Oocyte Competence and Embryo Quality: A Comparative Study of In Vivo Immunization and In Vitro Antibody Supplementation.

Jingyu Ren, Fuhan Liu, Gang Liu, Biao Wang, Jie Zhu, Yongbin Liu, Yanfeng Dai

Abstract read

In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Melatonin Supplementation Increases Oocyte Recovery and Quality Associated with Altered Follicular Steroidogenesis and Redox Status in Dairy Cows.Antioxidants (Basel, Switzerland) · 2026
Article
Multi-Omics Analysis of the Effects ofInternational journal of molecular sciences · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jingyu RenKey Laboratory of Herbivorous Livestock Reproductive Regulation, National Sheep Genetic Evaluation Center, Inner Mongolia University, Hohhot 010030, China.ORCID 0000-0002-0048-3052

Fuhan LiuKey Laboratory of Herbivorous Livestock Reproductive Regulation, National Sheep Genetic Evaluation Center, Inner Mongolia University, Hohhot 010030, China.

Gang LiuKey Laboratory of Herbivorous Livestock Reproductive Regulation, National Sheep Genetic Evaluation Center, Inner Mongolia University, Hohhot 010030, China.ORCID 0000-0002-5180-3765

Biao WangDepartment of Animal Genetics, Breeding, and Reproduction, College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010070, China.

Jie ZhuBeijing Jingwa Agricultural Science & Technology Innovation Center, Beijing 101205, China.

Yongbin LiuKey Laboratory of Herbivorous Livestock Reproductive Regulation, National Sheep Genetic Evaluation Center, Inner Mongolia University, Hohhot 010030, China.

Yanfeng DaiKey Laboratory of Herbivorous Livestock Reproductive Regulation, National Sheep Genetic Evaluation Center, Inner Mongolia University, Hohhot 010030, China.

Funding

Inner Mongolia Electric Power Survey & Design Institute (China) 2017ZD04Inner Mongolia Key Laboratory for Molecular Regulation of the Cell 2021PT0002Key technologies research and development program of Inner Mongolia 2021GG0402Major science and technology projects of Inner Mongolia 2020ZD0003National Natural Science Foundation of China 31272445, 31360548Open Competition Sci-Tech Breakthrough Project of Inner Mongolia 2022JBGS0023

6 · The paper itself

Abstract

High-efficiency Ovum Pick-Up (OPU) and in vitro embryo production (IVP) are critical for the genetic improvement of high-value Wagyu cattle. However, oxidative stress and mitochondrial dysfunction during oocyte maturation remain major bottlenecks limiting blastocyst yield. This study investigated the role of inhibin in Wagyu oocyte competence through two independent proof-of-concept approaches. In the in vivo active immunization model, thirty Wagyu donors were immunized with a recombinant inhibin protein (INHA group), resulting in a significant increase in the number of recovered cumulus-oocyte complexes (COCs) (461 vs. 279,

Indexed as

inhibinmitochondriaoocyte competenceOPU-IVPoxidative stressWagyu cattle

Identifiers

PMID42072057

DOI10.3390/antiox15040414

PMCPMC13114022

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.