SynthesisMedicine2026
Effect of exercise rehabilitation during neoadjuvant chemotherapy before esophageal cancer surgery on perioperative outcomes: A systematic review and meta-analysis.
Synthesis in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExercise rehabilitation during neoadjuvant chemotherapy (NAT) prior to esophageal cancer (EC) surgery has the potential to improve patients' physical function and accelerate postoperative recovery, but its effect remains unclear.
methodsA systematic review and meta-analysis were conducted to compare the clinical outcomes of exercise rehabilitation and usual care during preoperative NAT in patients with EC. Relevant literature in online databases EMBASE, PubMed, Web of Science, and ScienceDirect were thoroughly searched and then screened. The data related to clinical outcomes were extracted and synthesized by meta-analysis.
resultsA total of 10 studies involving 466 participants were included. Meta-analysis revealed significantly higher tumor response rates in the intervention group (risk difference = 0.28, 95% confidence interval [CI] = 0.12-0.44, P < .001), but no significant difference in T-stage downgrading rates between groups (risk difference = 0.11, 95% CI = -0.04 to 0.25, P = .138). The 6-minute walk distance was significantly greater in the intervention group (mean difference [MD] = 26.60 m, 95% CI = 6.61-46.58, P = .009), as was the daily step count (MD = 434.18 steps, 95% CI = 47.79-820.57, P = .028), and the peak oxygen uptake (MD = 2.55 mL/kg/min, 95% CI = 0.72-4.37, P = .023). No difference was found in maximal inspiratory pressure between groups (MD = 4.93, 95% CI = -3.09 to 12.96, P = .651).
conclusionExercise rehabilitation during NAT for EC may confer multidimensional benefits to patients' physical function. However, the current evidence level remains low due to the limited number and small sample sizes of the included studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.