ArticlePest management science2026
CYP6AB328-mediated spinetoram resistance via N-demethylation in Tuta absoluta: A potential resistance monitoring marker.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTuta absoluta, a major pest of solanaceous crops, has rapidly evolved resistance to spinosyn insecticides, causing significant damage to global crops. Our previous study demonstrated that CYP6AB328 plays an important role in the development of spinetoram resistance. However, the direct metabolic role of this detoxification enzyme in spinetoram metabolism remains unclear.
resultsIn this study, we conducted a docking analysis between CYP6AB328 and spinetoram. Our docking analysis showed a good binding affinity between CYP6AB328 and spinetoram, with an energy of less than -6.0 kcal mol
conclusionsThese findings provide valuable insights into the molecular mechanisms underlying detoxification of spinetoram and support the development of a candidate molecular marker for monitoring spinetoram resistance in the field populations, thereby contributing to improved pest management strategies. © 2026 Society of Chemical Industry.
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