ArticleEpigenetics & chromatin2026
Temporal stratification of promoter-proximal versus enhancer VDR binding directs vitamin D-responsive transcription.
Article in Epigenetics & chromatin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exploratory multi-omics analysis suggests context-dependent immune responses to vitamin DFrontiers in immunology · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe active vitamin D metabolite 1,25-dihydroxyvitamin D
resultsHere, we present a time-resolved analysis of VDR-mediated gene regulation in human THP-1 monocytes, integrating VDR ChIP-seq profiles at 40 min, 4, 8, and 24 h with matched transcriptome data following stimulation with 1,25(OH)
conclusionsTogether, these findings define a hierarchical, multi-layered model of vitamin D signaling in which early, promoter-proximal VDR binding is strongly associated with establishment of a transcriptionally competent core program, while later enhancer-mediated and indirect mechanisms progressively expand and diversify the response.
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