Evidence map›Paper›PMID 42071229›Full record

ArticleInfectious diseases of poverty2026

Influenza vaccine hesitancy versus uptake in seven Chinese megacities: a cross-sectional survey.

Tao Li, Qian Xiong, Peixin Wu

Erratum issuedAbstract read
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Article in Infectious diseases of poverty, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Tao Li *School of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Qian Xiong *School of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Peixin WuSchool of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. 13601313061@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfluenza vaccine hesitancy remains a major barrier to achieving adequate vaccination coverage, particularly in densely populated urban areas with aging populations. Seven Chinese megacities are especially vulnerable to influenza transmission, yet evidence on drivers of vaccine hesitancy in these contexts remains limited. This study aimed to assess the prevalence and determinants of influenza vaccine hesitancy (IVH) among urban populations to inform strategies for improving vaccine uptake in China.

methodsWe conducted a multi-city cross-sectional survey from March to June 2025 across seven Chinese megacities (Beijing, Shanghai, Guangzhou, Shenzhen, Tianjin, Chongqing, and Chengdu). Participants were selected using a stratified sampling strategy within communities; eligible participants were residents (aged ≥ 18 years) who had lived in the selected communities for at least six months. Data on demographic, socioeconomic, attitudinal factors, and behavioural factors were collected. Multivariable logistic regression was used to identify factors associated with IVH and pre-season influenza vaccine uptake.

resultsA total of 8689 participants were included. Overall, 45% of participants were classified as vaccine hesitant, while the self-reported influenza vaccination coverage for the 2024 season was 30%. Substantial variation in hesitancy was observed across megacities. Older adults (≥ 65 years) were less likely to report IVH than younger adults (18-44 years) [adjusted odds ratio (aOR) = 0.72, 95% confidence interval (CI): 0.55-0.93] and more likely to be vaccinated (aOR = 1.63, 95% CI: 1.35-1.96). Psychosocial factors were the strongest predictors of hesitancy, particularly low perceived vaccine benefit (aOR = 11.18, 95% CI: 8.45-14.64) and low trust in health authorities (aOR = 17.13, 95% CI: 13.51-21.71). Vaccination uptake was primarily associated with behavioural factors, especially prior COVID-19 vaccination (aOR = 0.32, 95% CI: 0.25-0.39).

conclusionsInfluenza vaccination in Chinese megacities is driven by a mix of demographic, psychosocial, and behavioural factors. Targeted strategies addressing both hesitancy and uptake are needed to improve coverage and reduce influenza transmission.

Indexed as

Influenza, HumanInfluenza VaccinesVaccinationVaccination HesitancyAdolescentAdultAgedChinaCitiesCross-Sectional StudiesFemaleHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedUrban PopulationInfluenza VaccinesChinaInfluenzaMegacityVaccination coverageVaccine hesitancy

Identifiers

PMID42071229
PMCPMC13137521

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.